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NCT04997486 · ClinicalTrials.gov registry record · NA
The Effect of Time-restricted Eating on Liver Metabolism
A NA study, sponsored by University of California, Davis.
- Completed
- Registry status
- NA
- Development phase
- 5
- Enrollment target
NCT04997486 is a NA study that has completed, run by University of California, Davis. The registered enrollment target is 5 participants.
The verdict
NCT04997486, a NA study, has completed, sponsored by University of California, Davis.
- COMPLETED
- Registry status
- NA
- Development phase
- 5 participants
- Enrollment target
Study Summary
Numerous studies have established the role of nutrition on obesity and its related metabolic diseases, which together affect a billion individuals worldwide. Evidence indicate that meal timing regulates numerous metabolic processes suggesting that meal time manipulation may be a simple intervention against obesity and its metabolic diseases. Time-restricted eating (TRE) is a dietary manipulation that involves restricting food intake to 6-10 h/day with no energy intake the rest of the day. In rodents, TRE significantly decreases hepatic steatosis and dyslipidemia, while it supports a healthier hepatic cellular content even without caloric restriction, potentially by alternating activation of nutrient sensing mechanisms and effects on circadian oscillations. However, an understanding of the effect of TRE on liver health in people is not clear. Accordingly, we will conduct a randomized controlled trial in people with overweight/obesity and hepatic steatosis to determine the effect of 9 h TRE for 12 weeks, on key metabolic outcomes in liver health: 1) intrahepatic triglyceride content using magnetic resonance imaging; 2) de novo lipogenesis during fasting and postprandial conditions using administration of deuterated water in conjunction with mathematical modeling. The proposed study will enable us to determine the effect of meal timing on metabolic function in people with NAFLD.
Interventions
- BEHAVIORAL Time restricted eating
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2021-07-20 |
| Est. Completion | 2024-03-07 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04997486
The ClinicalTrials.gov registry entry for NCT04997486 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 5 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of California, Davis, which has 657 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Time restricted eating is the first listed.
NCT04997486 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04997486 about?
NCT04997486 is a clinical study titled "The Effect of Time-restricted Eating on Liver Metabolism". Numerous studies have established the role of nutrition on obesity and its related metabolic diseases, which together affect a billion individuals worldwide. Evidence indicate that meal timing regulates numerous metabolic processes suggesting that meal time manipulation may be a simple intervention ...
What is the current status of trial NCT04997486?
This trial is currently completed. It is a NA study. The enrollment target is 5 participants. The study started on 2021-07-20. Estimated completion is 2024-03-07.
What interventions are being tested in trial NCT04997486?
The interventions under investigation include: Time restricted eating (BEHAVIORAL).
Who is sponsoring clinical trial NCT04997486?
This trial is sponsored by University of California, Davis, which has 657 total clinical trials registered on ClinicalTrials.gov.
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