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ACTIVE NOT RECRUITING Phase 3

Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

NCT04975997 · View on ClinicalTrials.gov ↗

Study Summary

This is a multicenter, two-stage, randomized, controlled, open-label, Phase 3 study comparing the efficacy and safety of iberdomide in combination with dexamethasone and daratumumab (IberDd) versus daratumumab, bortezomib, and dexamethasone (DVd) in participants with relapsed or refractory multiple myeloma (RRMM).

Conditions Studied

Interventions

  • DRUG Dexamethasone
  • DRUG Daratumumab
  • DRUG Iberdomide
  • DRUG Bortezomib

Study Locations (20)

Florida

  • Local Institution - 029 — Fort Myers
  • Local Institution - 693 — Ocala
  • Local Institution - 028 — St. Petersburg
  • Local Institution - 045 — Tamarac
  • Local Institution - 034 — West Palm Beach
  • Local Institution - 685 — Weston

California

  • Local Institution - 641 — Cerritos
  • Local Institution - 681 — Fountain Valley
  • Local Institution - 047 — Los Angeles
  • Local Institution - 684 — Newport

Louisiana

  • Local Institution - 041 — Alexandria
  • Local Institution - 682 — Baton Rouge
  • Local Institution - 027 — Baton Rouge

Arkansas

  • Local Institution - 035 — Hot Springs

Connecticut

  • Local Institution - 033 — New Haven

Georgia

  • Local Institution - 018 — Atlanta

Illinois

  • Local Institution - 640 — Elk Grove Village

Indiana

  • Local Institution - 697 — Dyer

Trial Details

FieldValue
Enrollment Target 864 participants
Start Date 2022-06-23
Est. Completion 2032-06-25
Phase Phase 3

Sponsor

Celgene

73 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04975997

The ClinicalTrials.gov registry entry for NCT04975997 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 864 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Celgene, which has 73 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Multiple Myeloma appearing as the primary indexed condition, and to 4 interventions — of which Dexamethasone is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04975997 reports 20 study locations spanning 10 distinct geographic areas — top geographies include Florida, California, Louisiana. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04975997 about?

NCT04975997 is a clinical study titled "Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)". This is a multicenter, two-stage, randomized, controlled, open-label, Phase 3 study comparing the efficacy and safety of iberdomide in combination with dexamethasone and daratumumab (IberDd) versus daratumumab, bortezomib, and dexamethasone (DVd) in participants with relapsed or refractory multiple ...

What is the current status of trial NCT04975997?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 864 participants. The study started on 2022-06-23. Estimated completion is 2032-06-25.

What conditions does trial NCT04975997 study?

This clinical trial studies the following conditions: Multiple Myeloma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04975997?

The interventions under investigation include: Dexamethasone (DRUG), Daratumumab (DRUG), Iberdomide (DRUG), Bortezomib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04975997?

This trial is sponsored by Celgene, which has 73 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04975997 being conducted?

This trial has 20 study locations across Arkansas, California, Connecticut, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial