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NCT04972929 · ClinicalTrials.gov registry record · NA
Effects of Chiropractic Care on Cytokine Levels in Multiple Sclerosis
A NA study, sponsored by University of Alabama at Birmingham.
- Completed
- Registry status
- NA
- Development phase
- 26
- Enrollment target
NCT04972929 is a NA study that has completed, run by University of Alabama at Birmingham. The registered enrollment target is 26 participants.
The verdict
NCT04972929, a NA study, has completed, sponsored by University of Alabama at Birmingham.
- COMPLETED
- Registry status
- NA
- Development phase
- 26 participants
- Enrollment target
Study Summary
Multiple sclerosis (MS) is an inflammatory autoimmune disease associated with an imbalance between pro- and anti-inflammatory markers (cytokines) resulting in a demyelinating and neurodegenerative disease. There is early evidence that spinal manipulation (chiropractic care) is better than control in influencing immune (cytokine) activity in asymptomatic participants, but few studies have been completed in participants with chronic inflammatory conditions, such as MS. The purpose of this project is to examine the immediate (after a single thoracic spinal manipulation treatment) and summative impact (after 8 thoracic spinal manipulation treatments occurring over 4 weeks) on pro-inflammatory (interleukin (IL) IL-1ß, IL-2, IL-6, Tumor necrosis factor-alpha) and anti-inflammatory (IL-4, IL-10) plasma cytokines 20 minutes and 2 hours after thoracic spinal manipulation in participants diagnosed with neuroinflammatory relapsing-remitting MS (RR-MS). Spinal manipulation treatment will be limited to the thoracic spine. Secondary outcomes will include determining the impact of 8 thoracic spinal manipulations on fatigue, cognitive processing speed, pain, depression, sleep, and motor function through questionnaires and performance of various in assessments such as the timed 25 foot walk test.
Interventions
- OTHER Spinal Manipulation
- OTHER Sham Spinal Manipulation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 26 participants |
| Start Date | 2022-12-15 |
| Est. Completion | 2025-03-12 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04972929
The ClinicalTrials.gov registry entry for NCT04972929 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 26 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Alabama at Birmingham, which has 1,160 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Spinal Manipulation is the first listed.
NCT04972929 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04972929 about?
NCT04972929 is a clinical study titled "Effects of Chiropractic Care on Cytokine Levels in Multiple Sclerosis". Multiple sclerosis (MS) is an inflammatory autoimmune disease associated with an imbalance between pro- and anti-inflammatory markers (cytokines) resulting in a demyelinating and neurodegenerative disease. There is early evidence that spinal manipulation (chiropractic care) is better than control in...
What is the current status of trial NCT04972929?
This trial is currently completed. It is a NA study. The enrollment target is 26 participants. The study started on 2022-12-15. Estimated completion is 2025-03-12.
What interventions are being tested in trial NCT04972929?
The interventions under investigation include: Spinal Manipulation (OTHER), Sham Spinal Manipulation (OTHER).
Who is sponsoring clinical trial NCT04972929?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
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