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NCT04962477 · ClinicalTrials.gov registry record
Understanding Host-pathogen Interaction in the Respiratory Mucosa During Pregnancy
A clinical trial, sponsored by Washington University School of Medicine.
- Completed
- Registry status
- 48
- Enrollment target
NCT04962477 is a clinical trial that has completed, run by Washington University School of Medicine. The registered enrollment target is 48 participants.
The verdict
NCT04962477 has completed, sponsored by Washington University School of Medicine.
- COMPLETED
- Registry status
- 48 participants
- Enrollment target
Study Summary
The clinical presentation of the ongoing coronavirus disease-19 (COVID-19) pandemic in pregnant women is unique with more asymptomatic infection, higher morbidity when symptomatic, yet without a difference in mortality rate. This is strikingly different from the high mortality observed during the past influenza A pandemics. Though both influenza A virus (IAV) and SARS-CoV-2 are single-stranded RNA viruses, the exquisite vulnerability of pregnant women to influenza A but not COVID-19 remains a mystery. Our objective, therefore, is to determine the mechanisms that predispose pregnant women to severe influenza A but confer protection against SARS-CoV-2 infection by examining the viral entry factors and innate immune response mechanisms in the nasal epithelium of pregnant vs. non-pregnant age-matched women.
Interventions
- OTHER Nasal brush sampling
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2022-03-02 |
| Est. Completion | 2023-09-27 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04962477
The ClinicalTrials.gov registry entry for NCT04962477 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 48 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Washington University School of Medicine, which has 1,502 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Nasal brush sampling is the first listed.
NCT04962477 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04962477 about?
NCT04962477 is a clinical study titled "Understanding Host-pathogen Interaction in the Respiratory Mucosa During Pregnancy". The clinical presentation of the ongoing coronavirus disease-19 (COVID-19) pandemic in pregnant women is unique with more asymptomatic infection, higher morbidity when symptomatic, yet without a difference in mortality rate. This is strikingly different from the high mortality observed during the pa...
What is the current status of trial NCT04962477?
This trial is currently completed. The enrollment target is 48 participants. The study started on 2022-03-02. Estimated completion is 2023-09-27.
What interventions are being tested in trial NCT04962477?
The interventions under investigation include: Nasal brush sampling (OTHER).
Who is sponsoring clinical trial NCT04962477?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
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