Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04959981 · ClinicalTrials.gov registry record · Phase 1
A Study of Anti-Cancer Therapies Targeting the MAPK Pathway in Patients With Advanced NSCLC
A Phase 1 study, sponsored by Erasca.
- Completed
- Registry status
- Phase 1
- Development phase
- 24
- Enrollment target
NCT04959981: Completed Phase 1 study, sponsored by Erasca.
NCT04959981 is a Phase 1 study that has completed, run by Erasca. The registered enrollment target is 24 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (60% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04959981, a Phase 1 study, has completed, sponsored by Erasca.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 24 participants
- Enrollment target
Study Summary
* To evaluate the safety and tolerability of escalating doses of ERAS-007 or ERAS-601 in combination with other cancer therapies in study participants with advanced non-small cell lung cancer (NSCLC). * To determine the Maximum Tolerated Dose (MTD) and/or Recommended Dose (RD) of ERAS-007 or ERAS-601 administered in combination with other cancer therapies. * To evaluate the antitumor activity of ERAS-007 or ERAS-601 in combination with other cancer therapies. * To evaluate the PK profiles of ERAS-007 or ERAS-601 and other cancer therapies when administered in combination.
Primary Outcome
Based on adverse events observed
Interventions
- DRUG Osimertinib
- DRUG Sotorasib
- DRUG ERAS-601
- DRUG ERAS-007
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2021-09-02 |
| Est. Completion | 2023-04-27 |
| Phase | Phase 1 |
What the finished NCT04959981 record still lists
NCT04959981 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (60% lower).
The record links to 0 conditions, and to 4 interventions - of which Osimertinib is the first listed.
NCT04959981 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04959981 about?
NCT04959981 is a clinical study titled "A Study of Anti-Cancer Therapies Targeting the MAPK Pathway in Patients With Advanced NSCLC". * To evaluate the safety and tolerability of escalating doses of ERAS-007 or ERAS-601 in combination with other cancer therapies in study participants with advanced non-small cell lung cancer (NSCLC). * To determine the Maximum Tolerated Dose (MTD) and/or Recommended Dose (RD) of ERAS-007 or ERAS-60...
What is the current status of trial NCT04959981?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 24 participants. The study started on 2021-09-02. Estimated completion is 2023-04-27.
What interventions are being tested in trial NCT04959981?
The interventions under investigation include: Osimertinib (DRUG), Sotorasib (DRUG), ERAS-601 (DRUG), ERAS-007 (DRUG).
Who is sponsoring clinical trial NCT04959981?
This trial is sponsored by Erasca, which has 8 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04959981's enrollment target sits among peer trials
24 1520th of 2000 higher than 405 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02331979 · 24 participants · NA
Improving Bladder Function in SCI by Neuromodulation
- NCT03096197 · 24 participants · NA
Exoskeleton and Spinal Cord Stimulation for SCI
- NCT03223922 · 24 participants · NA
Neurocognitive Functioning With Genu-Sparing Whole Brain Radiation Therapy for Brain Metastases
- NCT03326921 · 24 participants · Phase 1
HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI