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NCT04941443 · ClinicalTrials.gov registry record · Phase 4
Methadone and Medication Abortion
A Phase 4 study, sponsored by Boston Medical Center.
- Terminated
- Registry status
- Phase 4
- Development phase
- 4
- Enrollment target
NCT04941443: Clinical Trial Phase 4 study, sponsored by Boston Medical Center.
NCT04941443 is a Phase 4 study that was terminated before completion, run by Boston Medical Center. The registered enrollment target is 4 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04941443, a Phase 4 study, was terminated before completion, sponsored by Boston Medical Center.
- TERMINATED
- Registry status
- Phase 4
- Development phase
- 4 participants
- Enrollment target
Study Summary
Pain has been recognized to be the most common and predictable side effect of medication abortion, causing significant distress associated with the process. Yet there is little known about the appropriate management of pain during this process, with no current evidence based recommendations for optimal analgesic regimens during the first trimester. The goal of this study is to evaluate the efficacy of oral methadone for pain control during medication abortion. The current medication regimen used to perform medication abortion is a dose of mifepristone (antiprogesterone) orally, followed by a dose of misoprostol (prostaglandin analogue) 24 to 72 hours later. Patients are prescribed a standard dose of ibuprofen 600-800mg tabs for pain control during the process. The investigators will conduct a non-randomized, pilot study with 25 patients evaluated at the Boston Medical Center family planning clinic at 10 weeks of gestation or less for medication abortion.
Primary Outcome
Pain will be assessed using measured by an 11-point numeric visual analogue (VAS); (0-10) where 0 is equivalent to no pain and 10 is the worst pain. Higher scores are associated with more pain.
Interventions
- DRUG Ibuprofen
- DRUG Methadone Pill
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 4 participants |
| Start Date | 2021-10-04 |
| Est. Completion | 2022-03-01 |
| Phase | Phase 4 |
Why NCT04941443 stopped before completion
NCT04941443 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 4 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Ibuprofen is the first listed.
NCT04941443 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04941443 about?
NCT04941443 is a clinical study titled "Methadone and Medication Abortion". Pain has been recognized to be the most common and predictable side effect of medication abortion, causing significant distress associated with the process. Yet there is little known about the appropriate management of pain during this process, with no current evidence based recommendations for opti...
What is the current status of trial NCT04941443?
This trial is currently terminated. It is a Phase 4 study. The enrollment target is 4 participants. The study started on 2021-10-04. Estimated completion is 2022-03-01.
What interventions are being tested in trial NCT04941443?
The interventions under investigation include: Ibuprofen (DRUG), Methadone Pill (DRUG).
Who is sponsoring clinical trial NCT04941443?
This trial is sponsored by Boston Medical Center, which has 253 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04941443's enrollment target sits among peer trials
4 1994th of 2000 higher than 6 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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