Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 3

Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients

NCT04939090 · View on ClinicalTrials.gov ↗

Study Summary

This phase III trial compares the effects of olanzapine versus megestrol acetate in treating loss of appetite in patients with cancer that has spread to other places in the body (advanced). Olanzapine may stimulate and increase appetite. This study aims to find out if olanzapine is better than the usual approach (megestrol acetate) for stimulating appetite and preventing weight loss.

Interventions

  • OTHER Questionnaire Administration
  • DRUG Olanzapine
  • DRUG Megestrol Acetate

Study Locations (20)

California

  • Epic Care-Dublin — Dublin
  • Epic Care Partners in Cancer Care — Emeryville
  • Washington Hospital — Fremont
  • Contra Costa Regional Medical Center — Martinez
  • Bay Area Tumor Institute — Oakland
  • Zuckerberg San Francisco General Hospital — San Francisco
  • Dominican Santa Cruz Hospital — Santa Cruz
  • Epic Care Cyberknife Center — Walnut Creek

Arizona

  • Arizona Center for Cancer Care - Gilbert — Gilbert
  • CTCA at Western Regional Medical Center — Goodyear
  • Arizona Center for Cancer Care-Peoria — Peoria
  • Arizona Center for Cancer Care - Phoenix — Phoenix
  • Arizona Center for Cancer Care - Osborn — Scottsdale
  • Arizona Center for Cancer Care - Scottsdale — Scottsdale
  • Arizona Center for Cancer Care-Surprise — Surprise

Colorado

  • Rocky Mountain Cancer Centers-Aurora — Aurora
  • Rocky Mountain Cancer Centers-Boulder — Boulder
  • Rocky Mountain Cancer Centers - Centennial — Centennial
  • Rocky Mountain Cancer Centers-Midtown — Denver

Arkansas

  • NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro — Jonesboro

Trial Details

FieldValue
Enrollment Target 360 participants
Start Date 2022-01-03
Est. Completion 2027-12-31
Phase Phase 3

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04939090

The ClinicalTrials.gov registry entry for NCT04939090 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 360 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Alliance for Clinical Trials in Oncology, which has 147 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Advanced Malignant Solid Neoplasm appearing as the primary indexed condition, and to 3 interventions — of which Questionnaire Administration is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04939090 reports 20 study locations spanning 4 distinct geographic areas — top geographies include California, Arizona, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04939090 about?

NCT04939090 is a clinical study titled "Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients". This phase III trial compares the effects of olanzapine versus megestrol acetate in treating loss of appetite in patients with cancer that has spread to other places in the body (advanced). Olanzapine may stimulate and increase appetite. This study aims to find out if olanzapine is better than the u...

What is the current status of trial NCT04939090?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 360 participants. The study started on 2022-01-03. Estimated completion is 2027-12-31.

What conditions does trial NCT04939090 study?

This clinical trial studies the following conditions: Advanced Malignant Solid Neoplasm, Hematopoietic and Lymphoid Cell Neoplasm, Anorexia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04939090?

The interventions under investigation include: Questionnaire Administration (OTHER), Olanzapine (DRUG), Megestrol Acetate (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04939090?

This trial is sponsored by Alliance for Clinical Trials in Oncology, which has 147 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04939090 being conducted?

This trial has 20 study locations across Arizona, Arkansas, California, Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial