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Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)
NCT04924075 · View on ClinicalTrials.gov ↗
Study Summary
This is a study to evaluate the efficacy and safety of belzutifan monotherapy in participants with advanced pheochromocytoma/paraganglioma (PPGL), pancreatic neuroendocrine tumor (pNET), von Hippel-Lindau (VHL) disease-associated tumors, advanced wt (wild-type) gastrointestinal stromal tumor (wt GIST), or advanced solid tumors with hypoxia inducible factor-2 alpha (HIF-2α) related genetic alterations. The primary objective of the study is to evaluate the objective response rate (ORR) of belzutifan per response evaluation criteria in solid tumors version 1.1 (RECIST 1.1) by blinded independent central review (BICR).
Conditions Studied
Interventions
- DRUG Belzutifan
Study Locations (20)
Illinois
- Northwestern University - Robert H. Lurie Comprehensive Cancer Center ( Site 0130) — Chicago
- Northwestern Medicine Cancer Center - Warrenville ( Site 0134) — Warrenville
Maryland
- Johns Hopkins Hospital-Sidney Kimmel Comprehensive Cancer Center - Developmental Therapeutics ( Site 0108) — Baltimore
- National Institutes of Health ( Site 0125) — Bethesda
Tennessee
- SCRI Oncology Partners ( Site 7000) — Nashville
- Vanderbilt University Medical Center ( Site 0107) — Nashville
Region M. de Santiago
- FALP ( Site 2200) — Santiago
- Centro de Oncología de Precisión ( Site 2203) — Santiago
California
- Cedars-Sinai Medical Center ( Site 0110) — Los Angeles
Iowa
- University of Iowa ( Site 0104) — Iowa City
Massachusetts
- Massachusetts General Hospital ( Site 0111) — Boston
Michigan
- University of Michigan ( Site 0126) — Ann Arbor
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 322 participants |
| Start Date | 2021-08-12 |
| Est. Completion | 2029-06-04 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04924075
The ClinicalTrials.gov registry entry for NCT04924075 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 322 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 5 conditions, with Pancreatic Neuroendocrine Tumor appearing as the primary indexed condition, and to 1 intervention — of which Belzutifan is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04924075 reports 20 study locations spanning 16 distinct geographic areas — top geographies include Illinois, Maryland, Tennessee. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04924075 about?
NCT04924075 is a clinical study titled "Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)". This is a study to evaluate the efficacy and safety of belzutifan monotherapy in participants with advanced pheochromocytoma/paraganglioma (PPGL), pancreatic neuroendocrine tumor (pNET), von Hippel-Lindau (VHL) disease-associated tumors, advanced wt (wild-type) gastrointestinal stromal tumor (wt GIS...
What is the current status of trial NCT04924075?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 322 participants. The study started on 2021-08-12. Estimated completion is 2029-06-04.
What conditions does trial NCT04924075 study?
This clinical trial studies the following conditions: Pancreatic Neuroendocrine Tumor, Von Hippel-Lindau Disease, Pheochromocytoma/Paraganglioma, Advanced Gastrointestinal Stromal Tumor, HIF-2α Mutated Cancers. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04924075?
The interventions under investigation include: Belzutifan (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04924075?
This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04924075 being conducted?
This trial has 20 study locations across California, Illinois, Iowa, Maryland, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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