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NCT04858178 · ClinicalTrials.gov registry record · NA
Transcutaneous Spinal Cord Neuromodulation to Normalize Autonomic Phenotypes
A NA study, sponsored by Spaulding Rehabilitation Hospital.
- Completed
- Registry status
- NA
- Development phase
- 4
- Enrollment target
NCT04858178: Completed NA study, sponsored by Spaulding Rehabilitation Hospital.
NCT04858178 is a NA study that has completed, run by Spaulding Rehabilitation Hospital. The registered enrollment target is 4 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04858178, a NA study, has completed, sponsored by Spaulding Rehabilitation Hospital.
- COMPLETED
- Registry status
- NA
- Development phase
- 4 participants
- Enrollment target
Study Summary
This study looks to characterize autonomic nervous system dysfunction after spinal cord injury and identify the potential role that transcutaneous spinal cord stimulation may play at altering neuroregulation. The autonomic nervous system plays key parts in regulation of blood pressure, skin blood flow, and bladder health- all issues that individuals with spinal cord injury typically encounter complications. For both individuals with spinal cord injury and uninjured controls, experiments will utilize multiple parallel recordings to identify how the autonomic nervous system is able to inhibit and activate sympathetic signals. The investigators anticipate that those with autonomic dysfunction after spinal cord injury will exhibit abnormalities in these precise metrics. In both study populations, transcutaneous spinal cord stimulation will be added, testing previously advocated parameters to alter autonomic neuroregulation. In accomplishing this, the investigators hope to give important insights to how the autonomic nervous system works after spinal cord injury and if it's function can be improved utilizing neuromodulation.
Primary Outcome
Presence or absence of phase II on Valsalva maneuver testing, which takes approximately 15 seconds to complete. This will be repeated x3.
Interventions
- DIAGNOSTIC_TEST Tests of sympathetic inhibition
- DIAGNOSTIC_TEST Tests of sympathetic activation
- DIAGNOSTIC_TEST Testing of autonomic dysreflexia
- DEVICE Transcutaneous spinal cord stimulation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 4 participants |
| Start Date | 2022-02-17 |
| Est. Completion | 2022-11-14 |
| Phase | NA |
What the finished NCT04858178 record still lists
NCT04858178 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 4 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 4 interventions - of which Tests of sympathetic inhibition is the first listed.
NCT04858178 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04858178 about?
NCT04858178 is a clinical study titled "Transcutaneous Spinal Cord Neuromodulation to Normalize Autonomic Phenotypes". This study looks to characterize autonomic nervous system dysfunction after spinal cord injury and identify the potential role that transcutaneous spinal cord stimulation may play at altering neuroregulation. The autonomic nervous system plays key parts in regulation of blood pressure, skin blood fl...
What is the current status of trial NCT04858178?
This trial is currently completed. It is a NA study. The enrollment target is 4 participants. The study started on 2022-02-17. Estimated completion is 2022-11-14.
What interventions are being tested in trial NCT04858178?
The interventions under investigation include: Tests of sympathetic inhibition (DIAGNOSTIC_TEST), Tests of sympathetic activation (DIAGNOSTIC_TEST), Testing of autonomic dysreflexia (DIAGNOSTIC_TEST), Transcutaneous spinal cord stimulation (DEVICE).
Who is sponsoring clinical trial NCT04858178?
This trial is sponsored by Spaulding Rehabilitation Hospital, which has 101 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04858178's enrollment target sits among peer trials
4 1996th of 2000 higher than 5 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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