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NCT04838860 · ClinicalTrials.gov registry record · Phase 2
Siltuximab In Siltuximab-RElapsed/REfractory Multicentric CAstleman Disease
A Phase 2 study, sponsored by Recordati Group.
- Terminated
- Registry status
- Phase 2
- Development phase
- 22
- Enrollment target
NCT04838860: Clinical Trial Phase 2 study, sponsored by Recordati Group.
NCT04838860 is a Phase 2 study that was terminated before completion, run by Recordati Group. The registered enrollment target is 22 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (83% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04838860, a Phase 2 study, was terminated before completion, sponsored by Recordati Group.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 22 participants
- Enrollment target
Study Summary
Phase 2 study to investigate the safety, tolerability, and efficacy of administering increased siltuximab doses to patients with iMCD
Primary Outcome
Assess the clinical benefit response (CBR) of increased siltuximab doses in patients with IL-6-driven (C-reactive protein \[CRP\]-elevated and rising) idiopathic multicentric Castleman disease (iMCD) after disease progression on the standard siltuximab dose schedule. CBR defined as complete response (CR), partial response (PR), or stable disease (SD) lasting ≥12 weeks per Castleman Disease Collaborative Network Response Criteria (CDCNRC).
Interventions
- DRUG Siltuximab
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 22 participants |
| Start Date | 2021-03-31 |
| Est. Completion | 2021-04-01 |
| Phase | Phase 2 |
Why NCT04838860 stopped before completion
NCT04838860 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 22 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (83% lower).
The record links to 0 conditions, and to 1 intervention - of which Siltuximab is the first listed.
NCT04838860 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04838860 about?
NCT04838860 is a clinical study titled "Siltuximab In Siltuximab-RElapsed/REfractory Multicentric CAstleman Disease". Phase 2 study to investigate the safety, tolerability, and efficacy of administering increased siltuximab doses to patients with iMCD
What is the current status of trial NCT04838860?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 22 participants. The study started on 2021-03-31. Estimated completion is 2021-04-01.
What interventions are being tested in trial NCT04838860?
The interventions under investigation include: Siltuximab (DRUG).
Who is sponsoring clinical trial NCT04838860?
This trial is sponsored by Recordati Group, which has 11 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04838860's enrollment target sits among peer trials
22 1790th of 2000 higher than 207 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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