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NCT04836429 · ClinicalTrials.gov registry record · Phase 1
Photodynamic Therapy to Amplify the Response to Immunotherapy in Patients With Non-small Cell Lung Cancer With Pleural Disease
A Phase 1 study, sponsored by Roswell Park Cancer Institute.
- Terminated
- Registry status
- Phase 1
- Development phase
- 5
- Enrollment target
NCT04836429: Clinical Trial Phase 1 study, sponsored by Roswell Park Cancer Institute.
NCT04836429 is a Phase 1 study that was terminated before completion, run by Roswell Park Cancer Institute. The registered enrollment target is 5 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (92% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04836429, a Phase 1 study, was terminated before completion, sponsored by Roswell Park Cancer Institute.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 5 participants
- Enrollment target
Study Summary
This phase I trial evaluates the side effects of intraoperative photodynamic therapy with porfimer sodium in enhancing the response to immunotherapy with an immune checkpoint inhibitor drug in patients with non-small cell lung cancer with pleural disease. Photodynamic therapy is a technique that that works by combining a photosensitizing agent (porfimer sodium in this trial) and an intense light source to kill tumor cells. Photodynamic therapy may decrease the patients' symptoms and improve their quality of life.
Primary Outcome
Will be determined by recording the occurrence of SAE during the first 28 days post study-related immunotherapy. The SAE will be evaluated using the revised NCI Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.
Interventions
- PROCEDURE Video-Assisted Thoracic Surgery
- DRUG Porfimer Sodium
- DRUG Photodynamic Therapy
- DEVICE Intraoperative PDT
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2022-03-10 |
| Est. Completion | 2025-01-03 |
| Phase | Phase 1 |
Why NCT04836429 stopped before completion
NCT04836429 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (92% lower).
The record links to 0 conditions, and to 4 interventions - of which Video-Assisted Thoracic Surgery is the first listed.
NCT04836429 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04836429 about?
NCT04836429 is a clinical study titled "Photodynamic Therapy to Amplify the Response to Immunotherapy in Patients With Non-small Cell Lung Cancer With Pleural Disease". This phase I trial evaluates the side effects of intraoperative photodynamic therapy with porfimer sodium in enhancing the response to immunotherapy with an immune checkpoint inhibitor drug in patients with non-small cell lung cancer with pleural disease. Photodynamic therapy is a technique that tha...
What is the current status of trial NCT04836429?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 5 participants. The study started on 2022-03-10. Estimated completion is 2025-01-03.
What interventions are being tested in trial NCT04836429?
The interventions under investigation include: Video-Assisted Thoracic Surgery (PROCEDURE), Porfimer Sodium (DRUG), Photodynamic Therapy (DRUG), Intraoperative PDT (DEVICE).
Who is sponsoring clinical trial NCT04836429?
This trial is sponsored by Roswell Park Cancer Institute, which has 365 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04836429's enrollment target sits among peer trials
5 1989th of 2000 higher than 6 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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