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NCT04831424 · ClinicalTrials.gov registry record · NA
Mitochondrial Stress, Brain Imaging, and Epigenetics
A NA study, sponsored by Columbia University.
- Completed
- Registry status
- NA
- Development phase
- 110
- Enrollment target
NCT04831424: Completed NA study, sponsored by Columbia University.
NCT04831424 is a NA study that has completed, run by Columbia University. The registered enrollment target is 110 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (92% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04831424, a NA study, has completed, sponsored by Columbia University.
- COMPLETED
- Registry status
- NA
- Development phase
- 110 participants
- Enrollment target
Study Summary
The MiSBIE study collects biological, behavioral, psychosocial, neuropsychological, and brain imaging data in participants with either: normal mitochondrial function, individuals with the m.3243A\>G mitochondrial DNA (mtDNA) mutation, and individuals a single large-scale mtDNA deletion. These defects induce mitochondrial allostatic load (MAL). The 2-day protocol, plus home-based data collection, will provide a comprehensive assessment of the multi-systemic dysregulation associated with MAL or mitochondrial dysfunction, and the link to physical and mental health-related symptoms. Aim 1: Determine the influence of MAL on systemic AL biomarkers. Aim 2: Establish the influence of MAL on stress reactivity profiles. Aim 3. Examine the association between MAL and psychological functioning.
Primary Outcome
This is designed to measure cortisol reactivity to the trier social stress test (TSST), quantified from salivary cortisol (LC-MS) over an 8-timepoints timecourse. The elevation will be measured as the area under the curve (AUC) for the cortisol time course.
Interventions
- BEHAVIORAL Trier social stress test
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 110 participants |
| Start Date | 2018-06-12 |
| Est. Completion | 2024-05-03 |
| Phase | NA |
What the finished NCT04831424 record still lists
NCT04831424 is an interventional study that assigns participants to a tested intervention. The registered 110 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (92% lower).
The record links to 0 conditions, and to 1 intervention - of which Trier social stress test is the first listed.
NCT04831424 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04831424 about?
NCT04831424 is a clinical study titled "Mitochondrial Stress, Brain Imaging, and Epigenetics". The MiSBIE study collects biological, behavioral, psychosocial, neuropsychological, and brain imaging data in participants with either: normal mitochondrial function, individuals with the m.3243A\>G mitochondrial DNA (mtDNA) mutation, and individuals a single large-scale mtDNA deletion. These defect...
What is the current status of trial NCT04831424?
This trial is currently completed. It is a NA study. The enrollment target is 110 participants. The study started on 2018-06-12. Estimated completion is 2024-05-03.
What interventions are being tested in trial NCT04831424?
The interventions under investigation include: Trier social stress test (BEHAVIORAL).
Who is sponsoring clinical trial NCT04831424?
This trial is sponsored by Columbia University, which has 958 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04831424's enrollment target sits among peer trials
110 816th of 2000 higher than 1,176 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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