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NCT04815551 · ClinicalTrials.gov registry record · Phase 1
A Phase 1 Study of AV-380 in Healthy Subjects
A Phase 1 study, sponsored by AVEO Pharmaceuticals.
- Completed
- Registry status
- Phase 1
- Development phase
- 51
- Enrollment target
NCT04815551: Completed Phase 1 study, sponsored by AVEO Pharmaceuticals.
NCT04815551 is a Phase 1 study that has completed, run by AVEO Pharmaceuticals. The registered enrollment target is 51 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (15% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04815551, a Phase 1 study, has completed, sponsored by AVEO Pharmaceuticals.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 51 participants
- Enrollment target
Study Summary
This double-blinded, placebo-controlled, single ascending dose (SAD) study is designed to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity in healthy subjects of a single dose of AV-380. AV-380 is an immunoglobulin (Ig) G1 monoclonal antibody (mAb) intended to bind circulating human growth differentiation factor 15 (GDF-15), a cytokine involved in cancer-induced cachexia.
Interventions
- DRUG Placebo
- DRUG AV-380
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 51 participants |
| Start Date | 2021-02-22 |
| Est. Completion | 2022-01-14 |
| Phase | Phase 1 |
What the finished NCT04815551 record still lists
NCT04815551 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 51 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (15% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT04815551 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04815551 about?
NCT04815551 is a clinical study titled "A Phase 1 Study of AV-380 in Healthy Subjects". This double-blinded, placebo-controlled, single ascending dose (SAD) study is designed to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity in healthy subjects of a single dose of AV-380. AV-380 is an immunoglobulin (Ig) G1 monoclonal antibody (mAb) intended to bi...
What is the current status of trial NCT04815551?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 51 participants. The study started on 2021-02-22. Estimated completion is 2022-01-14.
What interventions are being tested in trial NCT04815551?
The interventions under investigation include: Placebo (DRUG), AV-380 (DRUG).
Who is sponsoring clinical trial NCT04815551?
This trial is sponsored by AVEO Pharmaceuticals, which has 27 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04815551's enrollment target sits among peer trials
51 969th of 2000 higher than 1,028 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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