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NCT04789330 · ClinicalTrials.gov registry record · Phase 4
Norepinephrine vs Phenylephrine During General Anesthesia
A Phase 4 study, sponsored by University of California, San Francisco.
- Completed
- Registry status
- Phase 4
- Development phase
- 3,626
- Enrollment target
NCT04789330: Completed Phase 4 study, sponsored by University of California, San Francisco.
NCT04789330 is a Phase 4 study that has completed, run by University of California, San Francisco. The registered enrollment target is 3,626 participants, above the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (600% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04789330, a Phase 4 study, has completed, sponsored by University of California, San Francisco.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 3,626 participants
- Enrollment target
Study Summary
50 million patients undergo surgery each year in the United States. Postoperative mortality is considered the third leading cause of death worldwide. Hypotension during surgery have been linked to increased postoperative morbidity and mortality. Episodes of hypotension during surgery are associated with an increased risk of acute kidney injury, stroke, cardiac events and death. Treating or preventing hypotension during general anesthesia and major surgery was found to improve outcomes. At this time, it is unclear what is the best vasopressor to maintain blood pressure during surgery under general anesthesia. With this pilot pragmatic trial, the investigators will explore the impact of norepinephrine (NE) or phenylephrine (PE) on post-operative events in patients undergoing major surgery with general anesthesia and needing vasopressors infusion to maintain their systemic arterial pressure.
Primary Outcome
First line vasopressor administration will be measured as a percent of total eligible participants with assigned vasopressor given during anesthesia time, up to 24 hours
Interventions
- DRUG Norepinephrine
- DRUG Phenylephrine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3,626 participants |
| Start Date | 2021-07-01 |
| Est. Completion | 2022-04-01 |
| Phase | Phase 4 |
What the finished NCT04789330 record still lists
NCT04789330 is an interventional study that assigns participants to a tested intervention. Its 3,626 participants enrollment target places it among the larger protocols in the corpus, above the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (600% higher).
The record links to 0 conditions, and to 2 interventions - of which Norepinephrine is the first listed.
NCT04789330 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04789330 about?
NCT04789330 is a clinical study titled "Norepinephrine vs Phenylephrine During General Anesthesia". 50 million patients undergo surgery each year in the United States. Postoperative mortality is considered the third leading cause of death worldwide. Hypotension during surgery have been linked to increased postoperative morbidity and mortality. Episodes of hypotension during surgery are associated ...
What is the current status of trial NCT04789330?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 3,626 participants. The study started on 2021-07-01. Estimated completion is 2022-04-01.
What interventions are being tested in trial NCT04789330?
The interventions under investigation include: Norepinephrine (DRUG), Phenylephrine (DRUG).
Who is sponsoring clinical trial NCT04789330?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04789330's enrollment target sits among peer trials
3,626 22nd of 2000 higher than 1,979 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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