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NCT04774250 · ClinicalTrials.gov registry record · Phase 2
Noise-Induced Hearing Loss-Acute Exposure Treatment (UA)
A Phase 2 study, sponsored by Washington University School of Medicine.
- Terminated
- Registry status
- Phase 2
- Development phase
- 3
- Enrollment target
NCT04774250: Clinical Trial Phase 2 study, sponsored by Washington University School of Medicine.
NCT04774250 is a Phase 2 study that was terminated before completion, run by Washington University School of Medicine. The registered enrollment target is 3 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04774250, a Phase 2 study, was terminated before completion, sponsored by Washington University School of Medicine.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 3 participants
- Enrollment target
Study Summary
The purpose of this study is to assess the safety and efficacy of zonisamide (ZNS) for the treatment of noise-induced hearing loss in adults.
Primary Outcome
The proportion of PTS-positive subjects defined as the ratio of PTS-positive subjects to total number of subjects within each study arm/group. Subjects defined as PTS-positive will demonstrate an increase in threshold that is ≥10 dB HL at any frequency from 2-6 kHz post-shooting as compared to baseline audiogram.
Interventions
- DRUG Placebo
- DRUG Zonisamide 100Mg Cap
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3 participants |
| Start Date | 2021-11-10 |
| Est. Completion | 2022-12-23 |
| Phase | Phase 2 |
Why NCT04774250 stopped before completion
NCT04774250 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 3 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT04774250 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04774250 about?
NCT04774250 is a clinical study titled "Noise-Induced Hearing Loss-Acute Exposure Treatment (UA)". The purpose of this study is to assess the safety and efficacy of zonisamide (ZNS) for the treatment of noise-induced hearing loss in adults.
What is the current status of trial NCT04774250?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 3 participants. The study started on 2021-11-10. Estimated completion is 2022-12-23.
What interventions are being tested in trial NCT04774250?
The interventions under investigation include: Placebo (DRUG), Zonisamide 100Mg Cap (DRUG).
Who is sponsoring clinical trial NCT04774250?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04774250's enrollment target sits among peer trials
3 2001st of 2000 the lowest of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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