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NCT04770155 · ClinicalTrials.gov registry record · Early Phase 1
Vascular Dysfunction in Black Individuals: Roles of Nitric Oxide and Endothelin-1
A Early Phase 1 study, sponsored by University of Mississippi Medical Center.
- Terminated
- Registry status
- Early Phase 1
- Development phase
- 8
- Enrollment target
NCT04770155: Clinical Trial Early Phase 1 study, sponsored by University of Mississippi Medical Center.
NCT04770155 is a Early Phase 1 study that was terminated before completion, run by University of Mississippi Medical Center. The registered enrollment target is 8 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (85% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04770155, a Early Phase 1 study, was terminated before completion, sponsored by University of Mississippi Medical Center.
- TERMINATED
- Registry status
- Early Phase 1
- Development phase
- 8 participants
- Enrollment target
Study Summary
The research aims of this proposal are: * Specific Aim 1: To test whether an increase in nitric oxide signaling can increase vasodilator responses in young Black individuals. * Specific Aim 2: To test whether a decrease in endothelin-1 signaling can increase vasodilator responses in young Black individuals.
Primary Outcome
The percent change in arterial diameter normalized to arterial shear rate during reperfusion after 5 minutes of circulatory occlusion.
Interventions
- DRUG Sildenafil 100 mg
- DIETARY_SUPPLEMENT Dietary Nitrates 400 mg
- DIETARY_SUPPLEMENT L-citrulline 3 g
- DRUG Bosentan 125 mg
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 8 participants |
| Start Date | 2021-05-27 |
| Est. Completion | 2021-09-20 |
| Phase | Early Phase 1 |
Why NCT04770155 stopped before completion
NCT04770155 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 8 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (85% lower).
The record links to 0 conditions, and to 4 interventions - of which Sildenafil 100 mg is the first listed.
NCT04770155 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04770155 about?
NCT04770155 is a clinical study titled "Vascular Dysfunction in Black Individuals: Roles of Nitric Oxide and Endothelin-1". The research aims of this proposal are: * Specific Aim 1: To test whether an increase in nitric oxide signaling can increase vasodilator responses in young Black individuals. * Specific Aim 2: To test whether a decrease in endothelin-1 signaling can increase vasodilator responses in young Black ind...
What is the current status of trial NCT04770155?
This trial is currently terminated. It is a Early Phase 1 study. The enrollment target is 8 participants. The study started on 2021-05-27. Estimated completion is 2021-09-20.
What interventions are being tested in trial NCT04770155?
The interventions under investigation include: Sildenafil 100 mg (DRUG), Dietary Nitrates 400 mg (DIETARY_SUPPLEMENT), L-citrulline 3 g (DIETARY_SUPPLEMENT), Bosentan 125 mg (DRUG).
Who is sponsoring clinical trial NCT04770155?
This trial is sponsored by University of Mississippi Medical Center, which has 96 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04770155's enrollment target sits among peer trials
8 1782nd of 2000 higher than 176 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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