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NCT04763759 · ClinicalTrials.gov registry record · Phase 1
Study to Evaluate Safety and Activity of TRL1068 in Prosthetic Joint Infections
A Phase 1 study, sponsored by Trellis Bioscience.
- Completed
- Registry status
- Phase 1
- Development phase
- 15
- Enrollment target
NCT04763759: Completed Phase 1 study, sponsored by Trellis Bioscience.
NCT04763759 is a Phase 1 study that has completed, run by Trellis Bioscience. The registered enrollment target is 15 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (75% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04763759, a Phase 1 study, has completed, sponsored by Trellis Bioscience.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 15 participants
- Enrollment target
Study Summary
TRL1068 is expected to eliminate the pathogen-protecting biofilm in the prosthetic joint and surrounding tissue, thus making these pathogens substantially more susceptible to established antibiotic treatment regimens. This initial study is designed to assess overall safety and pharmacokinetics (PK) of TRL1068. The overall goal of the development program is to demonstrate that TRL1068 can facilitate effectiveness of a single stage joint replacement or preservation of the original infected prosthetic joint in a substantial proportion of patients with PJI.
Primary Outcome
clinically significant abnormal physical exam findings will be reviewed
Interventions
- DRUG TRL1068, a human monoclonal antibody
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2021-02-08 |
| Est. Completion | 2024-03-13 |
| Phase | Phase 1 |
What the finished NCT04763759 record still lists
NCT04763759 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (75% lower).
The record links to 0 conditions, and to 1 intervention - of which TRL1068, a human monoclonal antibody is the first listed.
NCT04763759 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04763759 about?
NCT04763759 is a clinical study titled "Study to Evaluate Safety and Activity of TRL1068 in Prosthetic Joint Infections". TRL1068 is expected to eliminate the pathogen-protecting biofilm in the prosthetic joint and surrounding tissue, thus making these pathogens substantially more susceptible to established antibiotic treatment regimens. This initial study is designed to assess overall safety and pharmacokinetics (PK) ...
What is the current status of trial NCT04763759?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 15 participants. The study started on 2021-02-08. Estimated completion is 2024-03-13.
What interventions are being tested in trial NCT04763759?
The interventions under investigation include: TRL1068, a human monoclonal antibody (DRUG).
Who is sponsoring clinical trial NCT04763759?
This trial is sponsored by Trellis Bioscience, which has 4 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04763759's enrollment target sits among peer trials
15 1798th of 2000 higher than 157 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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