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NCT04748679 · ClinicalTrials.gov registry record · NA
Cognitive Behavioral Therapy (CBT) Study Evaluating the Updating of Persecutory Beliefs
A NA study, sponsored by Vanderbilt University Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 62
- Enrollment target
NCT04748679: Completed NA study, sponsored by Vanderbilt University Medical Center.
NCT04748679 is a NA study that has completed, run by Vanderbilt University Medical Center. The registered enrollment target is 62 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04748679, a NA study, has completed, sponsored by Vanderbilt University Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 62 participants
- Enrollment target
Study Summary
The purpose of this study is to examine how Bayesian belief updating changes throughout psychotherapeutic treatment for persecutory delusions. Specifically, individuals with a psychotic disorder diagnosis who endorse both a current persecutory delusion with strong conviction and significant worry will be recruited and randomized to receive either a CBT-based worry intervention for persecutory delusions or an active control condition (befriending therapy). The investigators will examine: 1) whether belief updating parameters change as delusion severity changes, 2) whether CBT contributes to greater change in belief updating parameters than befriending therapy, and 3) whether neural correlates of belief updating parameters, as measured using functional magnetic resonance imaging (fMRI), predict treatment response.
Primary Outcome
change in computational parameters after intervention
Interventions
- BEHAVIORAL Worry Intervention
- BEHAVIORAL Befriending
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 62 participants |
| Start Date | 2021-03-30 |
| Est. Completion | 2024-05-29 |
| Phase | NA |
What the finished NCT04748679 record still lists
NCT04748679 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 62 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 2 interventions - of which Worry Intervention is the first listed.
NCT04748679 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04748679 about?
NCT04748679 is a clinical study titled "Cognitive Behavioral Therapy (CBT) Study Evaluating the Updating of Persecutory Beliefs". The purpose of this study is to examine how Bayesian belief updating changes throughout psychotherapeutic treatment for persecutory delusions. Specifically, individuals with a psychotic disorder diagnosis who endorse both a current persecutory delusion with strong conviction and significant worry wi...
What is the current status of trial NCT04748679?
This trial is currently completed. It is a NA study. The enrollment target is 62 participants. The study started on 2021-03-30. Estimated completion is 2024-05-29.
What interventions are being tested in trial NCT04748679?
The interventions under investigation include: Worry Intervention (BEHAVIORAL), Befriending (BEHAVIORAL).
Who is sponsoring clinical trial NCT04748679?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04748679's enrollment target sits among peer trials
62 1157th of 2000 higher than 837 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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