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A Study of Ociperlimab With Tislelizumab Compared to Pembrolizumab in Participants With Untreated Lung Cancer
NCT04746924 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to evaluate the efficacy and safety of ociperlimab + tislelizumab compared with that of pembrolizumab in adults with PD-L1 high, locally advanced/recurrent or untreated metastatic NSCLC.
Conditions Studied
Interventions
- DRUG Pembrolizumab
- DRUG Placebo
- DRUG Tislelizumab
- DRUG Ociperlimab
Study Locations (20)
Queensland
- Pindara Private Hospital — Benowa
- The Prince Charles Hospital — Chermside
- Mater Cancer Care Centre — South Brisbane
- John Flynn Private Hospital — Tugun
New South Wales
- Concord Repatriation General Hospital — Concord
- Northern Cancer Institute — St Leonards
- Calvary Mater Newcastle — Waratah
California
- Providence Medical Foundation St Jude Heritage Healthcare — Fullerton
- Valkyrie Clinical Trials — Los Angeles
Florida
- Ocala Oncology Center Pl Dba Florida Cancer Affiliates Ocala — Ocala
- Advent Health Cancer Institute — Orlando
Other
- Centro Medical Austral — Buenos Aires
- Centro Para La Atencion Del Paciente Oncologico (Caipo) — San Miguel de Tucumán
Indiana
- Goshen Center For Cancer Care — Goshen
Kentucky
- Baptist Health Lexington — Lexington
Louisiana
- University Medical Center New Orleans West Jefferson Medical Center — New Orleans
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 662 participants |
| Start Date | 2021-06-08 |
| Est. Completion | 2026-03-31 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04746924
The ClinicalTrials.gov registry entry for NCT04746924 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 662 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is BeiGene, which has 91 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Non-small Cell Lung Cancer appearing as the primary indexed condition, and to 4 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04746924 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Queensland, New South Wales, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04746924 about?
NCT04746924 is a clinical study titled "A Study of Ociperlimab With Tislelizumab Compared to Pembrolizumab in Participants With Untreated Lung Cancer". The purpose of this study is to evaluate the efficacy and safety of ociperlimab + tislelizumab compared with that of pembrolizumab in adults with PD-L1 high, locally advanced/recurrent or untreated metastatic NSCLC.
What is the current status of trial NCT04746924?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 662 participants. The study started on 2021-06-08. Estimated completion is 2026-03-31.
What conditions does trial NCT04746924 study?
This clinical trial studies the following conditions: Non-small Cell Lung Cancer, NSCLC. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04746924?
The interventions under investigation include: Pembrolizumab (DRUG), Placebo (DRUG), Tislelizumab (DRUG), Ociperlimab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04746924?
This trial is sponsored by BeiGene, which has 91 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04746924 being conducted?
This trial has 20 study locations across California, Florida, Indiana, Kentucky, Louisiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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