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NCT04741542 · ClinicalTrials.gov registry record · Phase 1
Safety of SP-420 in the Treatment of Transfusional Iron Overload
A Phase 1 study, sponsored by The University of Texas Health Science Center at San Antonio.
- Terminated
- Registry status
- Phase 1
- Development phase
- 2
- Enrollment target
NCT04741542: Clinical Trial Phase 1 study, sponsored by The University of Texas Health Science Center at San Antonio.
NCT04741542 is a Phase 1 study that was terminated before completion, run by The University of Texas Health Science Center at San Antonio. The registered enrollment target is 2 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04741542, a Phase 1 study, was terminated before completion, sponsored by The University of Texas Health Science Center at San Antonio.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 2 participants
- Enrollment target
Study Summary
This study enrolls patients with myelodysplastic syndrome (MDS) and myelofibrosis (MFS), with transfusional iron overload and treats them with the investigational iron chelator, SP-420. SP-420 may be better tolerated and safer than commercially available iron chelators. Iron chelation therapy (ICT) has been shown to improve outcomes in iron overload, but adherence is poor due to problems related to ease of administration, tolerability, and safety.
Primary Outcome
Count of adverse events induced by SP-420
Interventions
- DRUG SP-420
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2 participants |
| Start Date | 2021-03-09 |
| Est. Completion | 2024-01-10 |
| Phase | Phase 1 |
Why NCT04741542 stopped before completion
NCT04741542 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 2 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 1 intervention - of which SP-420 is the first listed.
NCT04741542 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04741542 about?
NCT04741542 is a clinical study titled "Safety of SP-420 in the Treatment of Transfusional Iron Overload". This study enrolls patients with myelodysplastic syndrome (MDS) and myelofibrosis (MFS), with transfusional iron overload and treats them with the investigational iron chelator, SP-420. SP-420 may be better tolerated and safer than commercially available iron chelators. Iron chelation therapy (ICT) ...
What is the current status of trial NCT04741542?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 2 participants. The study started on 2021-03-09. Estimated completion is 2024-01-10.
What interventions are being tested in trial NCT04741542?
The interventions under investigation include: SP-420 (DRUG).
Who is sponsoring clinical trial NCT04741542?
This trial is sponsored by The University of Texas Health Science Center at San Antonio, which has 378 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04741542's enrollment target sits among peer trials
2 2000th of 2000 the lowest of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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