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NCT04729075 · ClinicalTrials.gov registry record
Associations Between COVID-19 ARDS Treatment, Clinical Trajectories and Liberation From Mechanical Ventilator - an Analysis of the NorthCARDS Dataset
A clinical trial, sponsored by Northwell Health.
- Completed
- Registry status
- 1,800
- Enrollment target
NCT04729075 is a clinical trial that has completed, run by Northwell Health. The registered enrollment target is 1,800 participants.
The verdict
NCT04729075 has completed, sponsored by Northwell Health.
- COMPLETED
- Registry status
- 1,800 participants
- Enrollment target
Study Summary
The mortality rates associated with COVID-19 related ARDS (COVIDARDS) have varied from observational reports from around the world. This has ranged from 44% (28 day mortality) in the UK to 36% (28 day mortality from ICU admission) in Italian studies, to 32% (all-cause 28 day mortality) in Spain. Predictive models have identified risk factors for COVID-19 hospitalized patients' mortality to include male sex, obesity, age, obesity, comorbidities including chronic lung disease and hypertension, as well as biomarkers including high levels of D-Dimer, LDH and CRP. In addition, practice patterns, such as drugs that were administered, timing of mechanical ventilation and adherence to established lung protective ventilation protocols are known to be variable across sites and have changed over time. The investigators propose to analyze outcomes for patients with COVIDARDS within the NorthCARDS dataset (a dataset of over 1500 patients with COVID-19 related ARDS across the Northwell Health System in the NYC metropolitan region and Long Island, NY) to understand differences in hospital survival and in the time to liberation from mechanical ventilation, specifically looking at the associations between baseline patient factors, changes in biomarkers, respiratory function and hemodynamics over time, and treatments administered. The analyses will be based on three hypotheses: H.1. Worsening trajectories of: oxygenation index (OI), respiratory system compliance (C), and inflammatory markers will be associated with lower hospital survival. H.2. Higher duration of deep sedation and paralytics will be associated with greater time to liberation from mechanical ventilation. This risk will be increased in patients with worsening trajectories of OI, C, and inflammatory markers over time. H.3. Type of mechanical ventilator, specifically the time on portable mechanical ventilator, is associated with hospital mortality and with inability to liberate from mechanical ventilator despite cont
Interventions
- OTHER ARDS and COVID19 treatments
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,800 participants |
| Start Date | 2021-01-19 |
| Est. Completion | 2021-01-19 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04729075
The ClinicalTrials.gov registry entry for NCT04729075 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 1,800 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Northwell Health, which has 370 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which ARDS and COVID19 treatments is the first listed.
NCT04729075 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04729075 about?
NCT04729075 is a clinical study titled "Associations Between COVID-19 ARDS Treatment, Clinical Trajectories and Liberation From Mechanical Ventilator - an Analysis of the NorthCARDS Dataset". The mortality rates associated with COVID-19 related ARDS (COVIDARDS) have varied from observational reports from around the world. This has ranged from 44% (28 day mortality) in the UK to 36% (28 day mortality from ICU admission) in Italian studies, to 32% (all-cause 28 day mortality) in Spain. Pre...
What is the current status of trial NCT04729075?
This trial is currently completed. The enrollment target is 1,800 participants. The study started on 2021-01-19. Estimated completion is 2021-01-19.
What interventions are being tested in trial NCT04729075?
The interventions under investigation include: ARDS and COVID19 treatments (OTHER).
Who is sponsoring clinical trial NCT04729075?
This trial is sponsored by Northwell Health, which has 370 total clinical trials registered on ClinicalTrials.gov.
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