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NCT04704869 · ClinicalTrials.gov registry record · Phase 3
Early Use of Cryoprecipitate With Major Hemorrhage Protocol (MHP) Activation
A Phase 3 study of Trauma Injury, sponsored by Bryan Cotton.
- Completed
- Registry status
- Phase 3
- Development phase
- 1,604
- Enrollment target
- 20
- Study locations
NCT04704869: Completed Phase 3 study of Trauma Injury, sponsored by Bryan Cotton.
NCT04704869 is a Phase 3 study of Trauma Injury that has completed, run by Bryan Cotton. The registered enrollment target is 1,604 participants, above the 394-participant average among 15 other Trauma Injury trials with a reported enrollment target (307% higher). The trial reports 20 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04704869, a Phase 3 study of Trauma Injury, has completed, sponsored by Bryan Cotton.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 1,604 participants
- Enrollment target
- 20
- Study locations
Study Summary
The purpose of this trial is to compare standard of care (SOC) massive transfusion protocol to SOC massive transfusion protocol plus early use of cryoprecipitate (within 90 minutes of emergency department arrival).
Primary Outcome
Mortality from any cause
Conditions Studied
Interventions
- BIOLOGICAL Cryoprecipitate
- BIOLOGICAL Red Blood Cells
- BIOLOGICAL Plasma
- BIOLOGICAL Platelets
- BIOLOGICAL Whole Blood
Study Locations (20)
Other
- Queen Elizabeth Hospital - Birmingham
- Royal Sussex County Hospital - Brighton
- Southmead Hospital - Bristol
- Addenbrooke's Hospital - Cambridge
- University Hospital of Wales - Cardiff
- University Hospital of Coventry and Warwickshire - Coventry
- Hull Royal Infirmary - Hull
- Leeds General Infirmary - Leeds
- University Hospital Aintree - Liverpool
- Royal London Hospital - London
- King's College Hospital - London
- St. George's Hospital - London
- St. Mary's Hospital - London
- Manchester Royal Infirmary - Manchester
- Salford Royal Hospital - Manchester
- James Cook University Hospital - Middlesbrough
- Royal Victoria Infirmary - Newcastle upon Tyne
- Queens Medical Centre - Nottingham
- John Radcliffe Hospital - Oxford
Texas
- The University of Texas Health Science Center at Houston - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,604 participants |
| Start Date | 2017-01 |
| Est. Completion | 2022-11-01 |
| Phase | Phase 3 |
What the finished NCT04704869 record still lists
NCT04704869 is an interventional study that assigns participants to a tested intervention. Its 1,604 participants enrollment target places it among the larger protocols in the corpus, above the 394-participant average among 15 other Trauma Injury trials with a reported enrollment target (307% higher).
The record links to 1 condition, with Trauma Injury appearing as the primary indexed condition, and to 5 interventions - of which Cryoprecipitate is the first listed.
NCT04704869 names 20 study sites across 2 states, led by Other, Texas.
Frequently Asked Questions
What is clinical trial NCT04704869 about?
NCT04704869 is a clinical study titled "Early Use of Cryoprecipitate With Major Hemorrhage Protocol (MHP) Activation". The purpose of this trial is to compare standard of care (SOC) massive transfusion protocol to SOC massive transfusion protocol plus early use of cryoprecipitate (within 90 minutes of emergency department arrival).
What is the current status of trial NCT04704869?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 1,604 participants. The study started on 2017-01. Estimated completion is 2022-11-01.
What conditions does trial NCT04704869 study?
This clinical trial studies the following conditions: Trauma Injury.
What interventions are being tested in trial NCT04704869?
The interventions under investigation include: Cryoprecipitate (BIOLOGICAL), Red Blood Cells (BIOLOGICAL), Plasma (BIOLOGICAL), Platelets (BIOLOGICAL), Whole Blood (BIOLOGICAL).
Who is sponsoring clinical trial NCT04704869?
This trial is sponsored by Bryan Cotton, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04704869 being conducted?
This trial has 20 study locations across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Trauma Injury
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04704869's enrollment target sits among peer trials
1,604 2nd of 15 the highest of 15 other Trauma Injury trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Trauma Injury trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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