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NCT04702152 · ClinicalTrials.gov registry record · NA
The Effects of Direct Context Reactivation During Sleep on Memory
A NA study, sponsored by Northwestern University.
- Completed
- Registry status
- NA
- Development phase
- 38
- Enrollment target
NCT04702152: Completed NA study, sponsored by Northwestern University.
NCT04702152 is a NA study that has completed, run by Northwestern University. The registered enrollment target is 38 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04702152, a NA study, has completed, sponsored by Northwestern University.
- COMPLETED
- Registry status
- NA
- Development phase
- 38 participants
- Enrollment target
Study Summary
The context in which memories are encoded is a major factor influencing how memories are organized. Individual memories are bound to the context (e.g., the location, time and state of mind in which they are encoded) and this context is later reinstated to recall the details related to the memory. Although the role of context has been explored with regard to memory encoding and retrieval, its role during sleep-related memory consolidation has not been explored. Memories are thought to be reactivated during sleep, subsequently benefitting from the process. This study will use encephalography (EEG) in humans to consider several competing hypotheses regarding context's role in sleep reactivation, thereby enhancing the current understanding of how reactivation of memory over sleep relates to models of context and memory. Participants will learn to associate pictures of scenes to different sounds and to smaller images of items and animals, and then learn the spatial locations of these smaller images on a grid. Crucially, for half of these scenes, the sounds themselves will then also be linked directly to some of images during training. The associated sounds will then be unobtrusively presented during sleep, in a manner that has been shown to improve associated memories. The subsequent memory benefits will reveal whether (1) all images associated with the cued scene will benefit from cuing, demonstrating a context-reactivation effect; (2) only the images directly associated with presented sound will benefit from the cuing, demonstrating a item-reactivation effect; or (3) some composite of these two models. Regardless of which hypothesis is correct, the results will expand our current understanding regarding the role context plays in sleep consolidation.
Primary Outcome
The correct location of an image is compared with the position in which the participant has placed it. Measured in pixels on a computer screen.
Interventions
- BEHAVIORAL Targeted memory reactivation (sounds)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 38 participants |
| Start Date | 2020-09-15 |
| Est. Completion | 2021-11-30 |
| Phase | NA |
What the finished NCT04702152 record still lists
NCT04702152 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 38 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 1 intervention - of which Targeted memory reactivation (sounds) is the first listed.
NCT04702152 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04702152 about?
NCT04702152 is a clinical study titled "The Effects of Direct Context Reactivation During Sleep on Memory". The context in which memories are encoded is a major factor influencing how memories are organized. Individual memories are bound to the context (e.g., the location, time and state of mind in which they are encoded) and this context is later reinstated to recall the details related to the memory. Al...
What is the current status of trial NCT04702152?
This trial is currently completed. It is a NA study. The enrollment target is 38 participants. The study started on 2020-09-15. Estimated completion is 2021-11-30.
What interventions are being tested in trial NCT04702152?
The interventions under investigation include: Targeted memory reactivation (sounds) (BEHAVIORAL).
Who is sponsoring clinical trial NCT04702152?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04702152's enrollment target sits among peer trials
38 1538th of 2000 higher than 461 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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