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NCT04700163 · ClinicalTrials.gov registry record · Phase 1
RU Anti-SARS-CoV-2 (COVID-19) mAbs in Healthy Volunteers
A Phase 1 study, sponsored by Rockefeller University.
- Completed
- Registry status
- Phase 1
- Development phase
- 23
- Enrollment target
NCT04700163: Completed Phase 1 study, sponsored by Rockefeller University.
NCT04700163 is a Phase 1 study that has completed, run by Rockefeller University. The registered enrollment target is 23 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (62% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04700163, a Phase 1 study, has completed, sponsored by Rockefeller University.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 23 participants
- Enrollment target
Study Summary
This is a first-in-human, open label, single dose, dose-escalation phase 1 study to evaluate the safety and pharmacokinetics of a combination of two highly neutralizing anti-SARS-CoV-2 mAbs targeting two distinct epitopes on the receptor protein binding domain (RBD) of the SARS-CoV-2 spike protein in healthy volunteers.
Primary Outcome
The number of participants with treatment-related solicited and unsolicited grade 2 adverse events (including confirmed laboratory abnormalities).
Interventions
- BIOLOGICAL C144-LS and C-135-LS
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 23 participants |
| Start Date | 2021-01-11 |
| Est. Completion | 2022-02-02 |
| Phase | Phase 1 |
What the finished NCT04700163 record still lists
NCT04700163 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 23 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (62% lower).
The record links to 0 conditions, and to 1 intervention - of which C144-LS and C-135-LS is the first listed.
NCT04700163 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04700163 about?
NCT04700163 is a clinical study titled "RU Anti-SARS-CoV-2 (COVID-19) mAbs in Healthy Volunteers". This is a first-in-human, open label, single dose, dose-escalation phase 1 study to evaluate the safety and pharmacokinetics of a combination of two highly neutralizing anti-SARS-CoV-2 mAbs targeting two distinct epitopes on the receptor protein binding domain (RBD) of the SARS-CoV-2 spike protein i...
What is the current status of trial NCT04700163?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 23 participants. The study started on 2021-01-11. Estimated completion is 2022-02-02.
What interventions are being tested in trial NCT04700163?
The interventions under investigation include: C144-LS and C-135-LS (BIOLOGICAL).
Who is sponsoring clinical trial NCT04700163?
This trial is sponsored by Rockefeller University, which has 117 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04700163's enrollment target sits among peer trials
23 1596th of 2000 higher than 400 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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