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NCT04679311 · ClinicalTrials.gov registry record · Phase 2
Treatment of Angiotensin Converting Enzyme Inhibitor-induced Angioedema
A Phase 2 study, sponsored by Washington University School of Medicine.
- Terminated
- Registry status
- Phase 2
- Development phase
- 2
- Enrollment target
NCT04679311: Clinical Trial Phase 2 study, sponsored by Washington University School of Medicine.
NCT04679311 is a Phase 2 study that was terminated before completion, run by Washington University School of Medicine. The registered enrollment target is 2 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04679311, a Phase 2 study, was terminated before completion, sponsored by Washington University School of Medicine.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 2 participants
- Enrollment target
Study Summary
Angiotensin Converting Enzyme (ACE) inhibitors are among the most important and widely prescribed drugs. They reduce the morbidity and mortality associated with high blood pressure, heart disease, and kidney disease. Unfortunately, their use carries the risk of causing life-threatening airway swelling in some patients. There is currently no treatment for this condition. A novel treatment approach that may reduce or completely reverse the swelling will be tested.
Primary Outcome
The subjects' serum ACE activity will be assessed prior to treatment and 30 minutes after treatment and compared to determine if the treatment increases serum ACE activity
Interventions
- OTHER Normal Saline
- BIOLOGICAL High ACE Activity Fresh Frozen Plasma
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2 participants |
| Start Date | 2020-12-22 |
| Est. Completion | 2023-01-31 |
| Phase | Phase 2 |
Why NCT04679311 stopped before completion
NCT04679311 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 2 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 2 interventions - of which Normal Saline is the first listed.
NCT04679311 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04679311 about?
NCT04679311 is a clinical study titled "Treatment of Angiotensin Converting Enzyme Inhibitor-induced Angioedema". Angiotensin Converting Enzyme (ACE) inhibitors are among the most important and widely prescribed drugs. They reduce the morbidity and mortality associated with high blood pressure, heart disease, and kidney disease. Unfortunately, their use carries the risk of causing life-threatening airway swelli...
What is the current status of trial NCT04679311?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 2 participants. The study started on 2020-12-22. Estimated completion is 2023-01-31.
What interventions are being tested in trial NCT04679311?
The interventions under investigation include: Normal Saline (OTHER), High ACE Activity Fresh Frozen Plasma (BIOLOGICAL).
Who is sponsoring clinical trial NCT04679311?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04679311's enrollment target sits among peer trials
2 2001st of 2000 the lowest of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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