Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

NCT04676737 · ClinicalTrials.gov registry record · Phase 2

TTHX1114(NM141) in Combination With DWEK/DSO

A Phase 2 study, sponsored by Trefoil Therapeutics.

Completed
Registry status
Phase 2
Development phase
49
Enrollment target

NCT04676737: Completed Phase 2 study, sponsored by Trefoil Therapeutics.

NCT04676737 is a Phase 2 study that has completed, run by Trefoil Therapeutics. The registered enrollment target is 49 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (63% lower). According to ClinicalTrials.gov, the official US trial registry.

View on ClinicalTrials.gov ↗

View your shortlist →

The verdict

NCT04676737, a Phase 2 study, has completed, sponsored by Trefoil Therapeutics.

COMPLETED
Registry status
Phase 2
Development phase
49 participants
Enrollment target

Study Summary

Open label, single-treatment, with a concurrent non-treatment control

Primary Outcome

Change from baseline

Interventions

  • DRUG TTHX1114(NM141)

Trial Details

FieldValue
Enrollment Target 49 participants
Start Date 2021-02-01
Est. Completion 2023-01-13
Phase Phase 2
Trefoil Therapeutics

4 total trials

What the finished NCT04676737 record still lists

NCT04676737 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 49 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (63% lower).

The record links to 0 conditions, and to 1 intervention - of which TTHX1114(NM141) is the first listed.

NCT04676737 does not publish any study locations in the registry export this page uses.

Frequently Asked Questions

What is clinical trial NCT04676737 about?

NCT04676737 is a clinical study titled "TTHX1114(NM141) in Combination With DWEK/DSO". Open label, single-treatment, with a concurrent non-treatment control

What is the current status of trial NCT04676737?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 49 participants. The study started on 2021-02-01. Estimated completion is 2023-01-13.

What interventions are being tested in trial NCT04676737?

The interventions under investigation include: TTHX1114(NM141) (DRUG).

Who is sponsoring clinical trial NCT04676737?

This trial is sponsored by Trefoil Therapeutics, which has 4 total clinical trials registered on ClinicalTrials.gov.

How this trial's enrollment target compares

Where NCT04676737's enrollment target sits among peer trials

49 1261st of 2000 higher than 736 of 2,000 other Phase 2 trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

Nationwide trials with similar profiles

Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.

Similar enrollment target

  • NCT02704858 · 49 participants · Phase 1

    Safety and Efficacy Study in Recurrent or Progressive Grade III or IV IDH1 Mutated Glioma

  • NCT03516708 · 49 participants · Phase 1

    Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer

  • NCT03692429 · 49 participants · Phase 1

    alloSHRINK - Standard cHemotherapy Regimen and Immunotherapy With Allogeneic NKG2D-based CYAD-101 Chimeric Antigen Receptor T-cells

  • NCT04329494 · 49 participants · Phase 1

    PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer

Similar registry start date

  • NCT05962346 · started 2026-12 · NA

    Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia

  • NCT07125183 · started 2026-12 · Phase 2

    Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma

  • NCT07292298 · started 2026-11 · Phase 2

    Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

  • NCT04263285 · started 2026-10 · NA

    Treatment of Depression Post-SCI

Source: ClinicalTrials.gov NCT04676737, the US trial registry maintained by the National Library of Medicine. NCT04676737 (small enrollment · none site footprint · completed) retrieved and formatted by PlainTrial, see methodology.