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NCT04675151 · ClinicalTrials.gov registry record · Phase 2
Safety and Efficacy of Nyxol With Pilocarpine Eye Drops in Subjects With Presbyopia
A Phase 2 study, sponsored by Ocuphire Pharma.
- Completed
- Registry status
- Phase 2
- Development phase
- 150
- Enrollment target
NCT04675151: Completed Phase 2 study, sponsored by Ocuphire Pharma.
NCT04675151 is a Phase 2 study that has completed, run by Ocuphire Pharma. The registered enrollment target is 150 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (13% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04675151, a Phase 2 study, has completed, sponsored by Ocuphire Pharma.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 150 participants
- Enrollment target
Study Summary
The objectives of this study are: To evaluate the efficacy of Nyxol + Pilocarpine to improve DCNVA in subjects with presbyopia
Primary Outcome
The primary efficacy endpoint was the percent of subjects with ≥ 15 letters of improvement in photopic binocular DCNVA on Visit 2 at 1 hour with POS + LDP compared to placebo alone. The improvement in binocular DCNVA for each subject was relative to the subject's own baseline value (Visit 1).
Interventions
- OTHER Placebo
- DRUG Pilocarpine
- DRUG Phentolamine Ophthalmic Solution 0.75%
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2021-02-15 |
| Est. Completion | 2021-06-30 |
| Phase | Phase 2 |
What the finished NCT04675151 record still lists
NCT04675151 is an interventional study that assigns participants to a tested intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (13% higher).
The record links to 0 conditions, and to 3 interventions - of which Placebo is the first listed.
NCT04675151 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04675151 about?
NCT04675151 is a clinical study titled "Safety and Efficacy of Nyxol With Pilocarpine Eye Drops in Subjects With Presbyopia". The objectives of this study are: To evaluate the efficacy of Nyxol + Pilocarpine to improve DCNVA in subjects with presbyopia
What is the current status of trial NCT04675151?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 150 participants. The study started on 2021-02-15. Estimated completion is 2021-06-30.
What interventions are being tested in trial NCT04675151?
The interventions under investigation include: Placebo (OTHER), Pilocarpine (DRUG), Phentolamine Ophthalmic Solution 0.75% (DRUG).
Who is sponsoring clinical trial NCT04675151?
This trial is sponsored by Ocuphire Pharma, which has 14 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04675151's enrollment target sits among peer trials
150 455th of 2000 higher than 1,510 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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