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NCT04650841 · ClinicalTrials.gov registry record · Early Phase 1
The Role of the Opioid System in Placebo Effects on Pain and Social Rejection
A Early Phase 1 study, sponsored by Trustees of Dartmouth College.
- Not yet
- Registry status
- Early Phase 1
- Development phase
- 60
- Enrollment target
NCT04650841 is a Early Phase 1 study that has not yet begun recruiting, run by Trustees of Dartmouth College. The registered enrollment target is 60 participants.
The verdict
NCT04650841, a Early Phase 1 study, has not yet begun recruiting, sponsored by Trustees of Dartmouth College.
- NOT YET RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 60 participants
- Enrollment target
Study Summary
The current study probes the involvement of the opioid system in placebo effects on social pain, using the opioid antagonist naloxone. 60 participants who recently experienced an unwanted breakup will experience rejection-related stimuli and receive painful heat and pressure stimuli during fMRI scanning. Participants will be randomized to receive either a naloxone or saline nasal spray, and be informed that the spray is either saline, or an effective pain and negative emotion reducing agent.
Interventions
- DRUG Placebo Cream with Naloxone
- DRUG Control Cream with Naloxone
- DRUG Placebo Cream with Saline
- DRUG Control Cream with Saline
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2026-09-01 |
| Est. Completion | 2027-03-01 |
| Phase | Early Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04650841
The ClinicalTrials.gov registry entry for NCT04650841 describes a study currently listed as not yet recruiting, categorized as Early Phase 1. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Trustees of Dartmouth College, which has 31 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 4 interventions - of which Placebo Cream with Naloxone is the first listed.
NCT04650841 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04650841 about?
NCT04650841 is a clinical study titled "The Role of the Opioid System in Placebo Effects on Pain and Social Rejection". The current study probes the involvement of the opioid system in placebo effects on social pain, using the opioid antagonist naloxone. 60 participants who recently experienced an unwanted breakup will experience rejection-related stimuli and receive painful heat and pressure stimuli during fMRI scan...
What is the current status of trial NCT04650841?
This trial is currently not yet recruiting. It is a Early Phase 1 study. The enrollment target is 60 participants. The study started on 2026-09-01. Estimated completion is 2027-03-01.
What interventions are being tested in trial NCT04650841?
The interventions under investigation include: Placebo Cream with Naloxone (DRUG), Control Cream with Naloxone (DRUG), Placebo Cream with Saline (DRUG), Control Cream with Saline (DRUG).
Who is sponsoring clinical trial NCT04650841?
This trial is sponsored by Trustees of Dartmouth College, which has 31 total clinical trials registered on ClinicalTrials.gov.
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