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NCT04650841 · ClinicalTrials.gov registry record · Early Phase 1
The Role of the Opioid System in Placebo Effects on Pain and Social Rejection
A Early Phase 1 study, sponsored by Trustees of Dartmouth College.
- Not yet
- Registry status
- Early Phase 1
- Development phase
- 60
- Enrollment target
NCT04650841: Clinical Trial Early Phase 1 study, sponsored by Trustees of Dartmouth College.
NCT04650841 is a Early Phase 1 study that has not yet begun recruiting, run by Trustees of Dartmouth College. The registered enrollment target is 60 participants, above the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (13% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04650841, a Early Phase 1 study, has not yet begun recruiting, sponsored by Trustees of Dartmouth College.
- NOT YET RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 60 participants
- Enrollment target
Study Summary
The current study probes the involvement of the opioid system in placebo effects on social pain, using the opioid antagonist naloxone. 60 participants who recently experienced an unwanted breakup will experience rejection-related stimuli and receive painful heat and pressure stimuli during fMRI scanning. Participants will be randomized to receive either a naloxone or saline nasal spray, and be informed that the spray is either saline, or an effective pain and negative emotion reducing agent.
Primary Outcome
Pain ratings will be given on a 0-100 scale. 0 being "no pain at all" and 100 being "most pain imaginable in the context of this study."
Interventions
- DRUG Placebo Cream with Naloxone
- DRUG Control Cream with Naloxone
- DRUG Placebo Cream with Saline
- DRUG Control Cream with Saline
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2026-09-01 |
| Est. Completion | 2027-03-01 |
| Phase | Early Phase 1 |
What is known before NCT04650841 opens enrollment
NCT04650841 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, above the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (13% higher).
The record links to 0 conditions, and to 4 interventions - of which Placebo Cream with Naloxone is the first listed.
NCT04650841 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04650841 about?
NCT04650841 is a clinical study titled "The Role of the Opioid System in Placebo Effects on Pain and Social Rejection". The current study probes the involvement of the opioid system in placebo effects on social pain, using the opioid antagonist naloxone. 60 participants who recently experienced an unwanted breakup will experience rejection-related stimuli and receive painful heat and pressure stimuli during fMRI scan...
What is the current status of trial NCT04650841?
This trial is currently not yet recruiting. It is a Early Phase 1 study. The enrollment target is 60 participants. The study started on 2026-09-01. Estimated completion is 2027-03-01.
What interventions are being tested in trial NCT04650841?
The interventions under investigation include: Placebo Cream with Naloxone (DRUG), Control Cream with Naloxone (DRUG), Placebo Cream with Saline (DRUG), Control Cream with Saline (DRUG).
Who is sponsoring clinical trial NCT04650841?
This trial is sponsored by Trustees of Dartmouth College, which has 31 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04650841's enrollment target sits among peer trials
60 403rd of 2000 higher than 1,564 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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