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NCT04649112 · ClinicalTrials.gov registry record · Phase 1
Dose-escalation Study of Safety of PBCAR19B in Participants With CD19-expressing Malignancies
A Phase 1 study, sponsored by Precision BioSciences.
- Completed
- Registry status
- Phase 1
- Development phase
- 13
- Enrollment target
NCT04649112: Completed Phase 1 study, sponsored by Precision BioSciences.
NCT04649112 is a Phase 1 study that has completed, run by Precision BioSciences. The registered enrollment target is 13 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (78% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04649112, a Phase 1 study, has completed, sponsored by Precision BioSciences.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 13 participants
- Enrollment target
Study Summary
This is a Phase 1, nonrandomized, open-label, single-dose, dose-escalation, and dose-expansion study to evaluate the safety and clinical activity of PBCAR19B in adult study participants with CD-19 expressing malignancies.
Primary Outcome
To determine the maximum tolerated dose (MTD)
Interventions
- GENETIC PBCAR19B
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 13 participants |
| Start Date | 2021-06-16 |
| Est. Completion | 2023-09-30 |
| Phase | Phase 1 |
What the finished NCT04649112 record still lists
NCT04649112 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 13 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (78% lower).
The record links to 0 conditions, and to 1 intervention - of which PBCAR19B is the first listed.
NCT04649112 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04649112 about?
NCT04649112 is a clinical study titled "Dose-escalation Study of Safety of PBCAR19B in Participants With CD19-expressing Malignancies". This is a Phase 1, nonrandomized, open-label, single-dose, dose-escalation, and dose-expansion study to evaluate the safety and clinical activity of PBCAR19B in adult study participants with CD-19 expressing malignancies.
What is the current status of trial NCT04649112?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 13 participants. The study started on 2021-06-16. Estimated completion is 2023-09-30.
What interventions are being tested in trial NCT04649112?
The interventions under investigation include: PBCAR19B (GENETIC).
Who is sponsoring clinical trial NCT04649112?
This trial is sponsored by Precision BioSciences, which has 5 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04649112's enrollment target sits among peer trials
13 1847th of 2000 higher than 149 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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