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NCT04642976 · ClinicalTrials.gov registry record
Prospective Evaluation of CT Guided Ablation of Cardiac Ganglionated Plexi
A clinical trial, sponsored by University of Pennsylvania.
- Completed
- Registry status
- 30
- Enrollment target
NCT04642976: Completed study, sponsored by University of Pennsylvania.
NCT04642976 is a clinical trial that has completed, run by University of Pennsylvania. The registered enrollment target is 30 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04642976 has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- 30 participants
- Enrollment target
Study Summary
Despite progress made in treating atrial fibrillation with catheter ablation, outcomes remain suboptimal with pulmonary vein isolation alone. Ablation of ganglionated plexi (GP) has been shown to be beneficial in patients with atrial fibrillation although optimal strategies of localization of these regions have yet to be determined. The investigators aim to develop a novel strategy of CT guided GP localization to guide ablation in patients with atrial fibrillation. The investigators also aim to clarify the network of innervation between GP to clarify the optimal ablation strategy. This is an observational, single-center study evaluating feasibility and efficacy of CT and high frequency stimulation (HFS) guided GP mapping and ablation in patients with AF undergoing catheter ablation with pulmonary vein isolation. Patients will undergo HFS and CT guided mapping of GPs followed by allocation into one of 8 different GP ablation approaches in a non-randomized fashion.
Primary Outcome
Number of patients with HFS response identified within 3 pixels (0.625x3=1.875mm) of a location where CT identified epicardial adipose tissue.
Interventions
- DEVICE Ganglionated Plexi mapping and ablation using Natus Cortical Stimulator and standard ablation catheters
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2021-01-20 |
| Est. Completion | 2024-01-01 |
What the finished NCT04642976 record still lists
NCT04642976 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 30 participants, a relatively small participant target.
The record links to 0 conditions, and to 1 intervention - of which Ganglionated Plexi mapping and ablation using Natus Cortical Stimulator and standard ablation catheters is the first listed.
NCT04642976 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04642976 about?
NCT04642976 is a clinical study titled "Prospective Evaluation of CT Guided Ablation of Cardiac Ganglionated Plexi". Despite progress made in treating atrial fibrillation with catheter ablation, outcomes remain suboptimal with pulmonary vein isolation alone. Ablation of ganglionated plexi (GP) has been shown to be beneficial in patients with atrial fibrillation although optimal strategies of localization of these ...
What is the current status of trial NCT04642976?
This trial is currently completed. The enrollment target is 30 participants. The study started on 2021-01-20. Estimated completion is 2024-01-01.
What interventions are being tested in trial NCT04642976?
The interventions under investigation include: Ganglionated Plexi mapping and ablation using Natus Cortical Stimulator and standard ablation catheters (DEVICE).
Who is sponsoring clinical trial NCT04642976?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
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