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NCT04636138 · ClinicalTrials.gov registry record · NA
Pharmacogenomic Modulators of Impaired Exercise Adaptation in Statin Users
A NA study of HMG-CoA Reductase Inhibitor Toxicity, sponsored by University of Kansas Medical Center.
- Active
- Registry status
- NA
- Development phase
- 5
- Enrollment target
- 1
- Study location
NCT04636138 is a NA study of HMG-CoA Reductase Inhibitor Toxicity that is active but no longer recruiting, run by University of Kansas Medical Center. The registered enrollment target is 5 participants. The trial reports 1 study location across 1 state.
The verdict
NCT04636138, a NA study of HMG-CoA Reductase Inhibitor Toxicity, is active but no longer recruiting, sponsored by University of Kansas Medical Center.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 5 participants
- Enrollment target
- 1
- Study location
Study Summary
3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have beneficial effects (prevent stroke, heart attack) but also some bad ones (block some good effects of exercise). Individuals have genetic variations in proteins that metabolize/transport statins. The investigators hypothesize that these variations modulate the relationship between statin use and lack of benefit from exercise. The investigators will test this by having statin-users do supervised exercise for 6 weeks, measuring the cardiorespiratory fitness before/after and correlating this to genetic variations present in the participant.
Conditions Studied
Interventions
- OTHER Exercise
Study Locations (1)
Kansas
- University of Kansas Medical Center - Kansas City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2021-06-03 |
| Est. Completion | 2026-07-30 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04636138
The ClinicalTrials.gov registry entry for NCT04636138 describes a study currently listed as active not recruiting, categorized as NA. The registered enrollment target is 5 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Kansas Medical Center, which has 408 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with HMG-CoA Reductase Inhibitor Toxicity appearing as the primary indexed condition, and to 1 intervention - of which Exercise is the first listed.
NCT04636138 reports 1 study location spanning 1 distinct geographic area - top geographies include Kansas.
Frequently Asked Questions
What is clinical trial NCT04636138 about?
NCT04636138 is a clinical study titled "Pharmacogenomic Modulators of Impaired Exercise Adaptation in Statin Users". 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have beneficial effects (prevent stroke, heart attack) but also some bad ones (block some good effects of exercise). Individuals have genetic variations in proteins that metabolize/transport statins. The investigators hyp...
What is the current status of trial NCT04636138?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 5 participants. The study started on 2021-06-03. Estimated completion is 2026-07-30.
What conditions does trial NCT04636138 study?
This clinical trial studies the following conditions: HMG-CoA Reductase Inhibitor Toxicity.
What interventions are being tested in trial NCT04636138?
The interventions under investigation include: Exercise (OTHER).
Who is sponsoring clinical trial NCT04636138?
This trial is sponsored by University of Kansas Medical Center, which has 408 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04636138 being conducted?
This trial has 1 study location across Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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