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NCT04625283 · ClinicalTrials.gov registry record · Phase 4
The Impact of Perioperative Ketamine Infusion on Surgical Recovery
A Phase 4 study, sponsored by Vanderbilt University Medical Center.
- Completed
- Registry status
- Phase 4
- Development phase
- 1,570
- Enrollment target
NCT04625283: Completed Phase 4 study, sponsored by Vanderbilt University Medical Center.
NCT04625283 is a Phase 4 study that has completed, run by Vanderbilt University Medical Center. The registered enrollment target is 1,570 participants, above the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (203% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04625283, a Phase 4 study, has completed, sponsored by Vanderbilt University Medical Center.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 1,570 participants
- Enrollment target
Study Summary
In order to effectively treat surgical pain with the least amount of opioids required, a multi-modal approach must include medications with different mechanisms of actions at alternative receptors. In light of the opioid epidemic, medical providers at Vanderbilt University Medical Center (VUMC) are strategically combining these medications in a bundled pain-regimen after surgery. These regimens have been shown to decrease opioid consumption, improve surgical outcomes, and reduce hospital stays, thus coining the term 'enhanced recovery pathway'. The combination of these medications has an indisputable synergistic effect. However, it is unknown how each medication contributes individually to the overall efficacy of the pathway. This study will examine the effects of ketamine, within the constructs of a multimodal pain regimen, on a) length of stay, b) opioid consumption, and c) surgical outcomes after major abdominal surgery.
Primary Outcome
The participants length of stay, from anesthesia beginning to discharge, measured in days
Interventions
- DRUG Placebo
- DRUG Ketamine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,570 participants |
| Start Date | 2021-04-12 |
| Est. Completion | 2024-02-01 |
| Phase | Phase 4 |
What the finished NCT04625283 record still lists
NCT04625283 is an interventional study that assigns participants to a tested intervention. Its 1,570 participants enrollment target places it among the larger protocols in the corpus, above the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (203% higher).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT04625283 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04625283 about?
NCT04625283 is a clinical study titled "The Impact of Perioperative Ketamine Infusion on Surgical Recovery". In order to effectively treat surgical pain with the least amount of opioids required, a multi-modal approach must include medications with different mechanisms of actions at alternative receptors. In light of the opioid epidemic, medical providers at Vanderbilt University Medical Center (VUMC) are ...
What is the current status of trial NCT04625283?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 1,570 participants. The study started on 2021-04-12. Estimated completion is 2024-02-01.
What interventions are being tested in trial NCT04625283?
The interventions under investigation include: Placebo (DRUG), Ketamine (DRUG).
Who is sponsoring clinical trial NCT04625283?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04625283's enrollment target sits among peer trials
1,570 50th of 2000 higher than 1,951 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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