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NCT04595682 · ClinicalTrials.gov registry record · NA
Estradiol Effects on Alcohol Across the Menstrual Cycle
A NA study, sponsored by Mark Fillmore.
- Completed
- Registry status
- NA
- Development phase
- 100
- Enrollment target
NCT04595682: Completed NA study, sponsored by Mark Fillmore.
NCT04595682 is a NA study that has completed, run by Mark Fillmore. The registered enrollment target is 100 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (93% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04595682, a NA study, has completed, sponsored by Mark Fillmore.
- COMPLETED
- Registry status
- NA
- Development phase
- 100 participants
- Enrollment target
Study Summary
This study will provide the first rigorous integrative test of the hypothesis that rapid rises in estradiol (a female hormone) increase the rewarding and disinhibiting effects of alcohol and that such increased sensitivity correlates with increased alcohol use. Identification of the behavioral mechanisms by which estradiol surges can increase alcohol use would provide a critical advancement of neurobiological theory of alcohol abuse in women, an understudied area, as well as provide new directions for personalization of alcohol abuse treatment in women. In this study, naturally-cycling women will be examined daily over their menstrual cycle using an integrative combination of daily ecological assessments of hormone fluctuations and alcohol use along with strategically-timed laboratory tests of their acute sensitivity to the rewarding and disinhibiting effects of a controlled dose of alcohol.
Primary Outcome
Attentional bias is measured by the visual dot-probe task and provides an implicit assessment of the rewarding properties of alcohol as indicated by the degree to which an acute dose of alcohol increases the drinker's attention to alcohol cues is measured. Subjects look at images on a screen and their attention to various images is measured. An alcohol-related image and a neutral control image are presented briefly side-by-side, on a computer screen. An eye tracker embedded into the monitor prov
Interventions
- DRUG Placebo
- DRUG Alcohol
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2021-03-15 |
| Est. Completion | 2024-11-06 |
| Phase | NA |
What the finished NCT04595682 record still lists
NCT04595682 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (93% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT04595682 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04595682 about?
NCT04595682 is a clinical study titled "Estradiol Effects on Alcohol Across the Menstrual Cycle". This study will provide the first rigorous integrative test of the hypothesis that rapid rises in estradiol (a female hormone) increase the rewarding and disinhibiting effects of alcohol and that such increased sensitivity correlates with increased alcohol use. Identification of the behavioral mecha...
What is the current status of trial NCT04595682?
This trial is currently completed. It is a NA study. The enrollment target is 100 participants. The study started on 2021-03-15. Estimated completion is 2024-11-06.
What interventions are being tested in trial NCT04595682?
The interventions under investigation include: Placebo (DRUG), Alcohol (DRUG).
Who is sponsoring clinical trial NCT04595682?
This trial is sponsored by Mark Fillmore, which has 3 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04595682's enrollment target sits among peer trials
100 840th of 2000 higher than 1,081 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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