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COMPLETED Phase 2

A Study of Brentuximab Vedotin and CHP in Frontline Treatment of PTCL With Less Than 10% CD30 Expression

NCT04569032 · View on ClinicalTrials.gov ↗

Study Summary

This clinical trial will study brentuximab vedotin with CHP to find out if the drugs work for people who have certain types of peripheral T-cell lymphoma (PTCL). It will also find out what side effects occur when brentuximab vedotin and CHP are used together. A side effect is anything the drugs do besides treating cancer. CHP is a type of chemotherapy that uses three drugs (cyclophosphamide, doxorubicin, and prednisone). CHP is approved by the FDA to treat certain types of PTCL.

Conditions Studied

Interventions

  • DRUG prednisone
  • DRUG cyclophosphamide
  • DRUG doxorubicin
  • DRUG brentuximab vedotin

Study Locations (20)

Colorado

  • Rocky Mountain Cancer centers, LLP — Aurora
  • Rocky Mountain Cancer centers, LLP — Boulder
  • Rocky Mountain Cancer centers, LLP — Colorado Springs
  • Rocky Mountain Cancer centers, LLP — Denver
  • Rocky Mountain Cancer centers, LLP — Denver
  • Rocky Mountain Cancer centers, LLP — Lakewood
  • Rocky Mountain Cancer centers, LLP — Littleton
  • Rocky Mountain Cancer centers, LLP — Lone Tree
  • Rocky Mountain Cancer centers, LLP — Longmont
  • Rocky Mountain Cancer centers, LLP — Pueblo
  • Rocky Mountain Cancer centers, LLP — Thornton

Alabama

  • University of Alabama at Birmingham — Birmingham
  • University of Alabama at Birmingham — Birmingham

California

  • Stanford Cancer Center — Stanford
  • Stanford Hospital and Clinics, Investigational Drug Services — Stanford

Louisiana

  • Tulane Cancer Center — New Orleans
  • Tulane Medical Center — New Orleans

New York

  • Memorial Sloan Kettering Cancer Center David H. Koch Center for Cancer Care — New York
  • Memorial Sloan Kettering Cancer Center — New York

Ohio

  • Cleveland Clinic taussig Cancer Center Investigational Pharmacy — Cleveland

Trial Details

FieldValue
Enrollment Target 82 participants
Start Date 2020-11-12
Est. Completion 2026-01-12
Phase Phase 2

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04569032

The ClinicalTrials.gov registry entry for NCT04569032 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 82 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Seagen, a wholly owned subsidiary of Pfizer, which has 51 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Peripheral T-cell Lymphoma appearing as the primary indexed condition, and to 4 interventions — of which prednisone is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04569032 reports 20 study locations spanning 6 distinct geographic areas — top geographies include Colorado, Alabama, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04569032 about?

NCT04569032 is a clinical study titled "A Study of Brentuximab Vedotin and CHP in Frontline Treatment of PTCL With Less Than 10% CD30 Expression". This clinical trial will study brentuximab vedotin with CHP to find out if the drugs work for people who have certain types of peripheral T-cell lymphoma (PTCL). It will also find out what side effects occur when brentuximab vedotin and CHP are used together. A side effect is anything the drugs do b...

What is the current status of trial NCT04569032?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 82 participants. The study started on 2020-11-12. Estimated completion is 2026-01-12.

What conditions does trial NCT04569032 study?

This clinical trial studies the following conditions: Peripheral T-cell Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04569032?

The interventions under investigation include: prednisone (DRUG), cyclophosphamide (DRUG), doxorubicin (DRUG), brentuximab vedotin (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04569032?

This trial is sponsored by Seagen, a wholly owned subsidiary of Pfizer, which has 51 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04569032 being conducted?

This trial has 20 study locations across Alabama, California, Colorado, Louisiana, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial