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NCT04566562 · ClinicalTrials.gov registry record
Blood Brain Barrier Dysfunction and Postoperative Neurocognitive Disorders
A clinical trial, sponsored by University of California, Los Angeles.
- Completed
- Registry status
- 32
- Enrollment target
NCT04566562 is a clinical trial that has completed, run by University of California, Los Angeles. The registered enrollment target is 32 participants.
The verdict
NCT04566562 has completed, sponsored by University of California, Los Angeles.
- COMPLETED
- Registry status
- 32 participants
- Enrollment target
Study Summary
Postoperative neurocognitive disorders (PND), which include postoperative delirium and both acute and longlasting neurocognitive deficits, are a significant public health problem, leading to a cascade of deleterious complications. Older adults are particularly at-risk of developing PND both in the short and long term. Although age is consistently reported as an important risk factor, the exact pathophysiology of PND remains poorly understood, but may include postsurgery-compromised blood brain barrier (BBB) function. This project proposes that perioperative BBB dysfunction is associated with measurable brain morphologic findings in cognitive control areas that can be discovered with non-invasive magnetic resonance imaging (MRI). Patients scheduled for surgery with an age range of 65-75 years of age, will participate in brain diffusion-weighted pseudo-continuous arterial spin labeling (DW-pCASL) and diffusion tensor imaging (DTI), cognitive assessments, and evaluation of a BBB marker from blood (at baseline, at two weeks, and at six months after surgery). All patients will have a brain scan (MRI) within before surgery and two weeks and six months after surgery. During this visit cognitive function will be assessed. Patients will also be asked to participate in a blood draw.
Interventions
- DIAGNOSTIC_TEST Cognitive Testing
- DIAGNOSTIC_TEST Brain Imaging
- DIAGNOSTIC_TEST Blood Biomarkers
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 32 participants |
| Start Date | 2020-08-03 |
| Est. Completion | 2024-02-29 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04566562
The ClinicalTrials.gov registry entry for NCT04566562 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 32 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of California, Los Angeles, which has 897 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 3 interventions - of which Cognitive Testing is the first listed.
NCT04566562 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04566562 about?
NCT04566562 is a clinical study titled "Blood Brain Barrier Dysfunction and Postoperative Neurocognitive Disorders". Postoperative neurocognitive disorders (PND), which include postoperative delirium and both acute and longlasting neurocognitive deficits, are a significant public health problem, leading to a cascade of deleterious complications. Older adults are particularly at-risk of developing PND both in the s...
What is the current status of trial NCT04566562?
This trial is currently completed. The enrollment target is 32 participants. The study started on 2020-08-03. Estimated completion is 2024-02-29.
What interventions are being tested in trial NCT04566562?
The interventions under investigation include: Cognitive Testing (DIAGNOSTIC_TEST), Brain Imaging (DIAGNOSTIC_TEST), Blood Biomarkers (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT04566562?
This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.
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