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NCT04558983 · ClinicalTrials.gov registry record
A Natural History Study to Evaluate Functional and Anatomical Progression in Retinitis Pigmentosa
A clinical trial, sponsored by Johns Hopkins University.
- Terminated
- Registry status
- 32
- Enrollment target
NCT04558983: Clinical Trial study, sponsored by Johns Hopkins University.
NCT04558983 is a clinical trial that was terminated before completion, run by Johns Hopkins University. The registered enrollment target is 32 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04558983 was terminated before completion, sponsored by Johns Hopkins University.
- TERMINATED
- Registry status
- 32 participants
- Enrollment target
Study Summary
This study will assess the progression of RP as seen on newer modalities including spectral-domain optical coherence (SD-OCT) and macular assessment integrity (MAIA) microperimetry to evaluate disease status. Understanding the natural history of the disease is not only essential to monitoring and comparing patient populations in clinical trials. It is also fundamental in the predevelopment phase in order to optimize the study duration needed to observe a statistically significant outcome. Furthermore, since the progression of RP is usually slow, relying on traditional tests can take an unfeasible length of time to observe any meaningful changes and assess therapeutic efficacy for new drugs. Therefore, the results of this study will be beneficial in establishing reliable endpoints and outcome measures for future clinical trials. Such outcome measures may be able to detect treatment response with more precision. More importantly, investigators may be able to detect changes early enough to prevent irreversible vision loss.
Primary Outcome
Microperimetry (MAIA) will be used to test whether there is a change in sensitivity (dB) in the macula
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 32 participants |
| Start Date | 2020-06-11 |
| Est. Completion | 2024-12-20 |
Why NCT04558983 stopped before completion
NCT04558983 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 32 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT04558983 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04558983 about?
NCT04558983 is a clinical study titled "A Natural History Study to Evaluate Functional and Anatomical Progression in Retinitis Pigmentosa". This study will assess the progression of RP as seen on newer modalities including spectral-domain optical coherence (SD-OCT) and macular assessment integrity (MAIA) microperimetry to evaluate disease status. Understanding the natural history of the disease is not only essential to monitoring and co...
What is the current status of trial NCT04558983?
This trial is currently terminated. The enrollment target is 32 participants. The study started on 2020-06-11. Estimated completion is 2024-12-20.
Who is sponsoring clinical trial NCT04558983?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
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