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NCT04543825 · ClinicalTrials.gov registry record
Usefulness of Cardiopulmonary Exercise Testing for Cardiovascular Risk Estimation and Frailty Assessment in Liver Transplant Candidates
A clinical trial of Cardiovascular Diseases+Liver Transplantation, sponsored by Andres Duarte-Rojo.
- Completed
- Registry status
- 54
- Enrollment target
- 2
- Study locations
NCT04543825: Completed study of Cardiovascular Diseases+Liver Transplantation, sponsored by Andres Duarte-Rojo.
NCT04543825 is a study of Cardiovascular Diseases+Liver Transplantation that has completed, run by Andres Duarte-Rojo. The registered enrollment target is 54 participants. The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04543825, a study of Cardiovascular Diseases+Liver Transplantation, has completed, sponsored by Andres Duarte-Rojo.
- COMPLETED
- Registry status
- 54 participants
- Enrollment target
- 2
- Study locations
Study Summary
Patients undergoing liver transplantation (LT) have a high risk for cardiovascular disease (CVD). Frailty is a frequent condition among LT candidates. Together, CVD and frailty are major causes of morbidity and mortality before and after LT. Conventional methods to diagnose and predict CVD in LT candidates lack sensitivity and clinically relevant application. However, cardiopulmonary exercise testing (CPET) can directly estimate coronary artery disease, cirrhotic cardiomyopathy, and indirectly assess frailty. Such versatility of CPET has caused it to become the standard of care in many LT centers outside of the United States. In preliminary work (funded internally by the Pittsburgh Liver Research Center) that will be used to fund a more definitive study (RO1), the investigators plan to investigate CVD and frailty in LT candidates, both from existing standard of care (SOC) methods and CPET. The investigators expect results to improve the current capacity to assess and prognosticate CVD and frailty in LT, ultimately changing practice.
Primary Outcome
Agreement between cardiopulmonary exercise testing and cardiac stress testing, for the identification of subclinical coronary artery disease in liver transplant candidates.
Conditions Studied
Interventions
- DEVICE Cardiopulmonary exercise testing
Study Locations (2)
Arizona
- Mayo Clinic Arizona - Phoenix
Pennsylvania
- University of Pittsburgh Medical Center - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 54 participants |
| Start Date | 2020-09-25 |
| Est. Completion | 2022-05-31 |
What the finished NCT04543825 record still lists
NCT04543825 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 54 participants, a relatively small participant target.
The record links to 1 condition, with Cardiovascular Diseases+Liver Transplantation appearing as the primary indexed condition, and to 1 intervention - of which Cardiopulmonary exercise testing is the first listed.
NCT04543825 reports a single indexed study location in Arizona, Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT04543825 about?
NCT04543825 is a clinical study titled "Usefulness of Cardiopulmonary Exercise Testing for Cardiovascular Risk Estimation and Frailty Assessment in Liver Transplant Candidates". Patients undergoing liver transplantation (LT) have a high risk for cardiovascular disease (CVD). Frailty is a frequent condition among LT candidates. Together, CVD and frailty are major causes of morbidity and mortality before and after LT. Conventional methods to diagnose and predict CVD in LT can...
What is the current status of trial NCT04543825?
This trial is currently completed. The enrollment target is 54 participants. The study started on 2020-09-25. Estimated completion is 2022-05-31.
What conditions does trial NCT04543825 study?
This clinical trial studies the following conditions: Cardiovascular Diseases+Liver Transplantation.
What interventions are being tested in trial NCT04543825?
The interventions under investigation include: Cardiopulmonary exercise testing (DEVICE).
Who is sponsoring clinical trial NCT04543825?
This trial is sponsored by Andres Duarte-Rojo, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04543825 being conducted?
This trial has 2 study locations across Arizona, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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