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NCT04520178 · ClinicalTrials.gov registry record · Phase 2
Effects of 5HTP on the Injured Human Spinal Cord
A Phase 2 study of Spinal Cord Injuries, sponsored by University of Alberta.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 30
- Enrollment target
- 2
- Study locations
NCT04520178: Recruiting Phase 2 study of Spinal Cord Injuries, sponsored by University of Alberta.
NCT04520178 is a Phase 2 study of Spinal Cord Injuries that is actively recruiting participants, run by University of Alberta. The registered enrollment target is 30 participants, below the 61-participant average among 202 other Spinal Cord Injuries trials with a reported enrollment target (51% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04520178, a Phase 2 study of Spinal Cord Injuries, is actively recruiting participants, sponsored by University of Alberta.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 30 participants
- Enrollment target
- 2
- Study locations
Study Summary
This study will assess how the serotonin precursor, 5-HTP, alter nervous system excitability and motor function in individuals with spinal cord injuries of differing chronicity and severity. Participants will visit the lab on 4 separate occasions where they will be administered four different drugs in a randomized, double-blinded, placebo-controlled crossover design.
Primary Outcome
F waves
Conditions Studied
Interventions
- DRUG Placebo
- DRUG 5-Hydroxytryptophan
- DRUG 5-Hydroxytryptophan 100 MG
- DRUG Carbidopa
Study Locations (2)
Kentucky
- University of Louisville - Louisville
Alberta
- University of Alberta - Edmonton
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2020-07-01 |
| Est. Completion | 2026-12-30 |
| Phase | Phase 2 |
What NCT04520178 shows while recruiting
NCT04520178 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 61-participant average among 202 other Spinal Cord Injuries trials with a reported enrollment target (51% lower).
The record links to 1 condition, with Spinal Cord Injuries appearing as the primary indexed condition, and to 4 interventions - of which Placebo is the first listed.
NCT04520178 reports a single indexed study location in Kentucky, Alberta.
Frequently Asked Questions
What is clinical trial NCT04520178 about?
NCT04520178 is a clinical study titled "Effects of 5HTP on the Injured Human Spinal Cord". This study will assess how the serotonin precursor, 5-HTP, alter nervous system excitability and motor function in individuals with spinal cord injuries of differing chronicity and severity. Participants will visit the lab on 4 separate occasions where they will be administered four different drugs ...
What is the current status of trial NCT04520178?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 30 participants. The study started on 2020-07-01. Estimated completion is 2026-12-30.
What conditions does trial NCT04520178 study?
This clinical trial studies the following conditions: Spinal Cord Injuries.
What interventions are being tested in trial NCT04520178?
The interventions under investigation include: Placebo (DRUG), 5-Hydroxytryptophan (DRUG), 5-Hydroxytryptophan 100 MG (DRUG), Carbidopa (DRUG).
Who is sponsoring clinical trial NCT04520178?
This trial is sponsored by University of Alberta, which has 19 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04520178 being conducted?
This trial has 2 study locations across Kentucky, Alberta. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Spinal Cord Injuries
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04520178's enrollment target sits among peer trials
30 90th of 202 higher than 99 of 202 other Spinal Cord Injuries trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Spinal Cord Injuries trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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