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NCT04515407 · ClinicalTrials.gov registry record · NA
Plantarflexor PAS - Stroke
A NA study, sponsored by VA Office of Research and Development.
- Completed
- Registry status
- NA
- Development phase
- 10
- Enrollment target
NCT04515407: Completed NA study, sponsored by VA Office of Research and Development.
NCT04515407 is a NA study that has completed, run by VA Office of Research and Development. The registered enrollment target is 10 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04515407, a NA study, has completed, sponsored by VA Office of Research and Development.
- COMPLETED
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
Study Summary
The current project investigates a method called paired associative stimulation (PAS) which is known to influence nervous system function through a process called neuroplasticity. Here the investigators will target function of the ankle plantarflexor muscles because they are critically important to walking. The investigators will study adults who have walking dysfunction resulting from stroke. The study will test three ways of delivering PAS targeted towards brain-muscle connections serving the ankle plantarflexors. The overall goal is to improve functioning of the plantarflexors. The investigators believe that improving plantarflexor function will increase the likelihood of positive effects from gait retraining programs for people post-stroke. Participants will experience all three PAS methods in separate sessions. The investigators will compare differences in the size of these effects to identify the optimal method for delivery of PAS to the ankle plantarflexors. This study is a preliminary step to help us design a better clinical trial of combined PAS and gait retraining.
Primary Outcome
The difference in MEP size (area) post-PAS compared to pre-PAS will be quantified as the primary outcome for Aim 1. MEP size is considered an indicator of cortical/neural excitability. An increase in MEP size would suggest that PAS enhanced cortical excitability. MEP size can be expressed in either absolute/raw values or percentage change relative to baseline. A single session of PAS lasts 30-45 minutes.
Interventions
- OTHER PAS at Rest
- OTHER PAS - Active
- OTHER PAS - Walking
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2021-10-01 |
| Est. Completion | 2023-09-30 |
| Phase | NA |
What the finished NCT04515407 record still lists
NCT04515407 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 3 interventions - of which PAS at Rest is the first listed.
NCT04515407 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04515407 about?
NCT04515407 is a clinical study titled "Plantarflexor PAS - Stroke". The current project investigates a method called paired associative stimulation (PAS) which is known to influence nervous system function through a process called neuroplasticity. Here the investigators will target function of the ankle plantarflexor muscles because they are critically important to ...
What is the current status of trial NCT04515407?
This trial is currently completed. It is a NA study. The enrollment target is 10 participants. The study started on 2021-10-01. Estimated completion is 2023-09-30.
What interventions are being tested in trial NCT04515407?
The interventions under investigation include: PAS at Rest (OTHER), PAS - Active (OTHER), PAS - Walking (OTHER).
Who is sponsoring clinical trial NCT04515407?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04515407's enrollment target sits among peer trials
10 1927th of 2000 higher than 26 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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