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NCT04514757 · ClinicalTrials.gov registry record · NA
Transcutaneous (Tragus) Vagal Nerve Stimulation for Post-op Afib
A NA study, sponsored by University of California, Los Angeles.
- Completed
- Registry status
- NA
- Development phase
- 77
- Enrollment target
NCT04514757: Completed NA study, sponsored by University of California, Los Angeles.
NCT04514757 is a NA study that has completed, run by University of California, Los Angeles. The registered enrollment target is 77 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04514757, a NA study, has completed, sponsored by University of California, Los Angeles.
- COMPLETED
- Registry status
- NA
- Development phase
- 77 participants
- Enrollment target
Study Summary
Patients undergoing cardiac surgery are at high risk of developing atrial fibrillation (AF), with estimated rates of 30-50% and occurs at approximately 2-4 days after surgery. The autonomic nervous system is known to play a key role in AF. Animal studies have indicated that duration and inducibility of AF can be decreased with intermittent vagus nerve stimulation (VNS). In humans, literature suggests that transcutaneous (tragus) VNS (tVNS) can serve as a potentially non-invasive therapy for treatment of post-operative AF (POAF) by reducing inflammation and increasing atrial refractory period. The purpose of this study is to determine the value of tVNS in reducing the burden of POAF and days of hospitalization after cardiac surgery.
Primary Outcome
Incidence of post-operative atrial fibrillation for postoperative day 0-5 (postop day 0 is the day of the surgery and is the first day of the time frame and postoperative day 5 is the 6th day).
Interventions
- DEVICE active tVNS
- DEVICE sham tVNS
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 77 participants |
| Start Date | 2021-09-20 |
| Est. Completion | 2024-04-25 |
| Phase | NA |
What the finished NCT04514757 record still lists
NCT04514757 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 77 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 2 interventions - of which active tVNS is the first listed.
NCT04514757 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04514757 about?
NCT04514757 is a clinical study titled "Transcutaneous (Tragus) Vagal Nerve Stimulation for Post-op Afib". Patients undergoing cardiac surgery are at high risk of developing atrial fibrillation (AF), with estimated rates of 30-50% and occurs at approximately 2-4 days after surgery. The autonomic nervous system is known to play a key role in AF. Animal studies have indicated that duration and inducibility...
What is the current status of trial NCT04514757?
This trial is currently completed. It is a NA study. The enrollment target is 77 participants. The study started on 2021-09-20. Estimated completion is 2024-04-25.
What interventions are being tested in trial NCT04514757?
The interventions under investigation include: active tVNS (DEVICE), sham tVNS (DEVICE).
Who is sponsoring clinical trial NCT04514757?
This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04514757's enrollment target sits among peer trials
77 1062nd of 2000 higher than 939 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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