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NCT04487730 · ClinicalTrials.gov registry record · NA
Social Reward and Its Effect on Brain Functions in Psychotherapies for Mid- and Late-Life Depression
A NA study, sponsored by Weill Medical College of Cornell University.
- Completed
- Registry status
- NA
- Development phase
- 64
- Enrollment target
NCT04487730: Completed NA study, sponsored by Weill Medical College of Cornell University.
NCT04487730 is a NA study that has completed, run by Weill Medical College of Cornell University. The registered enrollment target is 64 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04487730, a NA study, has completed, sponsored by Weill Medical College of Cornell University.
- COMPLETED
- Registry status
- NA
- Development phase
- 64 participants
- Enrollment target
Study Summary
Abnormalities in the Positive Valence System (PVS) are associated with depressive symptoms and reduced behavioral activation in mid- and late-life. This study will investigate the engagement of the PVS during exposure to social rewards, part of a novel streamlined psychotherapy for mid- and late-life depression. Use of computational modeling will enable identification of neuroimaging and behavioral profiles associated with greater treatment response, and may guide future personalization of psychotherapy.
Primary Outcome
Calculated from fMRI scan. Validation of target engagement (resting state functional connectivity (rsFC) within the right hemisphere orbital prefrontal cortex (OFC), specifically between the lateral and medial regions of the OFC).
Interventions
- BEHAVIORAL "Engage & Connect" Psychotherapy
- BEHAVIORAL Symptom Review and Psychoeducation (SRP)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 64 participants |
| Start Date | 2020-10-15 |
| Est. Completion | 2024-08-19 |
| Phase | NA |
What the finished NCT04487730 record still lists
NCT04487730 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 64 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 2 interventions - of which "Engage & Connect" Psychotherapy is the first listed.
NCT04487730 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04487730 about?
NCT04487730 is a clinical study titled "Social Reward and Its Effect on Brain Functions in Psychotherapies for Mid- and Late-Life Depression". Abnormalities in the Positive Valence System (PVS) are associated with depressive symptoms and reduced behavioral activation in mid- and late-life. This study will investigate the engagement of the PVS during exposure to social rewards, part of a novel streamlined psychotherapy for mid- and late-lif...
What is the current status of trial NCT04487730?
This trial is currently completed. It is a NA study. The enrollment target is 64 participants. The study started on 2020-10-15. Estimated completion is 2024-08-19.
What interventions are being tested in trial NCT04487730?
The interventions under investigation include: "Engage & Connect" Psychotherapy (BEHAVIORAL), Symptom Review and Psychoeducation (SRP) (BEHAVIORAL).
Who is sponsoring clinical trial NCT04487730?
This trial is sponsored by Weill Medical College of Cornell University, which has 701 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04487730's enrollment target sits among peer trials
64 1147th of 2000 higher than 844 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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