Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04487041 · ClinicalTrials.gov registry record · Phase 4
Tfh Dysfunction in HIV and Aging
A Phase 4 study of Human Influenza, sponsored by University of Miami.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 400
- Enrollment target
- 1
- Study location
NCT04487041: Recruiting Phase 4 study of Human Influenza, sponsored by University of Miami.
NCT04487041 is a Phase 4 study of Human Influenza that is actively recruiting participants, run by University of Miami. The registered enrollment target is 400 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (23% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04487041, a Phase 4 study of Human Influenza, is actively recruiting participants, sponsored by University of Miami.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 400 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this research is to evaluate blood samples from HIV infected and non-HIV infected people to understand how aging and HIV infection affect the immune responses (body defenses against infection) to the flu vaccine.
Primary Outcome
Change in mean titers of Hemagglutination inhibition (HAI) antibody response will be measured using serum sample.
Conditions Studied
Interventions
- BIOLOGICAL Standard dose influenza vaccination
- BIOLOGICAL High dose influenza vaccination
Study Locations (1)
Florida
- University of Miami - Miami
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 400 participants |
| Start Date | 2020-10-30 |
| Est. Completion | 2026-12-30 |
| Phase | Phase 4 |
What NCT04487041 shows while recruiting
NCT04487041 is an interventional study that assigns participants to a tested intervention. The registered 400 participants enrollment target is mid-sized for trials with a published cap, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (23% lower).
The record links to 1 condition, with Human Influenza appearing as the primary indexed condition, and to 2 interventions - of which Standard dose influenza vaccination is the first listed.
NCT04487041 reports a single indexed study location in Florida.
Frequently Asked Questions
What is clinical trial NCT04487041 about?
NCT04487041 is a clinical study titled "Tfh Dysfunction in HIV and Aging". The purpose of this research is to evaluate blood samples from HIV infected and non-HIV infected people to understand how aging and HIV infection affect the immune responses (body defenses against infection) to the flu vaccine.
What is the current status of trial NCT04487041?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 400 participants. The study started on 2020-10-30. Estimated completion is 2026-12-30.
What conditions does trial NCT04487041 study?
This clinical trial studies the following conditions: Human Influenza.
What interventions are being tested in trial NCT04487041?
The interventions under investigation include: Standard dose influenza vaccination (BIOLOGICAL), High dose influenza vaccination (BIOLOGICAL).
Who is sponsoring clinical trial NCT04487041?
This trial is sponsored by University of Miami, which has 721 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04487041 being conducted?
This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04487041's enrollment target sits among peer trials
400 211th of 2000 higher than 1,785 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01665326 · 400 participants
Determination of CRIM Status and Longitudinal Follow-up of Individuals With Pompe Disease
- NCT02108054 · 400 participants · NA
Behavioral and Functional Task Development, Implementation, and Testing
- NCT02216500 · 400 participants · NA
Ketogenic Therapy Effects on Electrical and Metabolic Abnormalities in Epilepsy
- NCT02250352 · 400 participants
Core Biopsies for Establishing a Breast Tumor Tissue Repository
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI