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NCT04476758 · ClinicalTrials.gov registry record
Immune Profiles in CF Fungal Infection
A clinical trial, sponsored by University of Alabama at Birmingham.
- Completed
- Registry status
- 24
- Enrollment target
NCT04476758: Completed study, sponsored by University of Alabama at Birmingham.
NCT04476758 is a clinical trial that has completed, run by University of Alabama at Birmingham. The registered enrollment target is 24 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04476758 has completed, sponsored by University of Alabama at Birmingham.
- COMPLETED
- Registry status
- 24 participants
- Enrollment target
Study Summary
This study is investigating the role of allergic (Th2) inflammation in patients with Cystic Fibrosis (CF) and history of fungal infection and/or Allergic Bronchopulmonary Aspergillosis. Little is known about fungal infection in CF and conflicting results exist on whether this results in worse lung function over time. There is concern that persistent fungal infection can result in worse clinical outcome measures in patients with CF. Also, it is unclear how ABPA develops, but may be related to the amount of fungus a patient with CF is infected with. This study looks at inflammatory patterns and allergic responses to fungal elements to help identify biomarkers and signs of allergic disease in fungally infected patients with CF.
Primary Outcome
Difference in sputum Th2 biomarkers (ECP, IL4, IL5, IL10, IL13, and eosinophil count) in patients with CF with fungal infection with expected elevation of sputum Th2 biomarkers in patients with CF and ABPA compared to those without fungal infection and without ABPA.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2021-02-10 |
| Est. Completion | 2023-10-30 |
What the finished NCT04476758 record still lists
NCT04476758 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 24 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT04476758 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04476758 about?
NCT04476758 is a clinical study titled "Immune Profiles in CF Fungal Infection". This study is investigating the role of allergic (Th2) inflammation in patients with Cystic Fibrosis (CF) and history of fungal infection and/or Allergic Bronchopulmonary Aspergillosis. Little is known about fungal infection in CF and conflicting results exist on whether this results in worse lung f...
What is the current status of trial NCT04476758?
This trial is currently completed. The enrollment target is 24 participants. The study started on 2021-02-10. Estimated completion is 2023-10-30.
Who is sponsoring clinical trial NCT04476758?
This trial is sponsored by University of Alabama at Birmingham, which has 1,160 total clinical trials registered on ClinicalTrials.gov.
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