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NCT04464421 · ClinicalTrials.gov registry record · NA
SMART Effectiveness Trial
A NA study, sponsored by Karen Derefinko, PhD.
- Completed
- Registry status
- NA
- Development phase
- 48
- Enrollment target
NCT04464421: Completed NA study, sponsored by Karen Derefinko, PhD.
NCT04464421 is a NA study that has completed, run by Karen Derefinko, PhD. The registered enrollment target is 48 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04464421, a NA study, has completed, sponsored by Karen Derefinko, PhD.
- COMPLETED
- Registry status
- NA
- Development phase
- 48 participants
- Enrollment target
Study Summary
The current study piloted two psychosocial interventions developed to increase buprenorphine-naloxone adherence in individuals with opioid use disorder (OUD). Participants were randomized to receive either contingency management (CM) or a brief substance free activities session plus mindfulness (BSM) cognitive-behavioral intervention. Participants were 48 newly presenting patients from an OUD treatment clinic. The primary outcome was medication adherence, as measured by buprenorphine metabolite in urine and presence at 2 or more of 4 possible physician visits.
Primary Outcome
Defined as no negative buprenorphine urine tests and attendance of at least two visits.
Interventions
- BEHAVIORAL Contingency Management (CM)
- BEHAVIORAL Brief Motivational Intervention + Substance Free Activities Session + Mindfulness-Based Adherence Promotion (BSM)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2020-08-17 |
| Est. Completion | 2021-08-29 |
| Phase | NA |
What the finished NCT04464421 record still lists
NCT04464421 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 2 interventions - of which Contingency Management (CM) is the first listed.
NCT04464421 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04464421 about?
NCT04464421 is a clinical study titled "SMART Effectiveness Trial". The current study piloted two psychosocial interventions developed to increase buprenorphine-naloxone adherence in individuals with opioid use disorder (OUD). Participants were randomized to receive either contingency management (CM) or a brief substance free activities session plus mindfulness (BSM...
What is the current status of trial NCT04464421?
This trial is currently completed. It is a NA study. The enrollment target is 48 participants. The study started on 2020-08-17. Estimated completion is 2021-08-29.
What interventions are being tested in trial NCT04464421?
The interventions under investigation include: Contingency Management (CM) (BEHAVIORAL), Brief Motivational Intervention + Substance Free Activities Session + Mindfulness-Based Adherence Promotion (BSM) (BEHAVIORAL).
Who is sponsoring clinical trial NCT04464421?
This trial is sponsored by Karen Derefinko, PhD, which has 4 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04464421's enrollment target sits among peer trials
48 1381st of 2000 higher than 601 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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