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NCT04450212 · ClinicalTrials.gov registry record · NA
Vitamin K Supplementation Study in Healthy Volunteers (Aim 2B)
A NA study, sponsored by University of Washington.
- Terminated
- Registry status
- NA
- Development phase
- 106
- Enrollment target
NCT04450212 is a NA study that was terminated before completion, run by University of Washington. The registered enrollment target is 106 participants.
The verdict
NCT04450212, a NA study, was terminated before completion, sponsored by University of Washington.
- TERMINATED
- Registry status
- NA
- Development phase
- 106 participants
- Enrollment target
Study Summary
The overall purpose of this study is to determine how variation in the CYP4F2 gene modulates the synthesis of vitamin K-dependent clotting factors. We propose that the CYP4F2\*3 gene variant increases short- and long-term vitamin K concentrations in the liver by reducing the efficiency of vitamin K metabolism. The investigators will study the effect of vitamin K supplementation on two biomarkers of hepatic vitamin K concentration in groups with defined CYP4F2\*3 genotype. Specifically, the investigators will test for an association between our novel biomarkers of long-term (plasma Factor II proteoforms) and short-term (urinary K-Acid catabolites) hepatic vitamin K concentration and CYP4F2\*3 following a 10-day period of vitamin K supplementation in healthy volunteers.
Interventions
- GENETIC Phase I, Buccal Swab Collection for DNA Isolation
- DIETARY_SUPPLEMENT Phase II, Vitamin K (Vitacost) Supplementation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 106 participants |
| Start Date | 2017-08-25 |
| Est. Completion | 2023-07-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04450212
The ClinicalTrials.gov registry entry for NCT04450212 describes a study currently listed as terminated, categorized as NA. The registered enrollment target is 106 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Washington, which has 1,048 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Phase I, Buccal Swab Collection for DNA Isolation is the first listed.
NCT04450212 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04450212 about?
NCT04450212 is a clinical study titled "Vitamin K Supplementation Study in Healthy Volunteers (Aim 2B)". The overall purpose of this study is to determine how variation in the CYP4F2 gene modulates the synthesis of vitamin K-dependent clotting factors. We propose that the CYP4F2\*3 gene variant increases short- and long-term vitamin K concentrations in the liver by reducing the efficiency of vitamin K ...
What is the current status of trial NCT04450212?
This trial is currently terminated. It is a NA study. The enrollment target is 106 participants. The study started on 2017-08-25. Estimated completion is 2023-07-31.
What interventions are being tested in trial NCT04450212?
The interventions under investigation include: Phase I, Buccal Swab Collection for DNA Isolation (GENETIC), Phase II, Vitamin K (Vitacost) Supplementation (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT04450212?
This trial is sponsored by University of Washington, which has 1,048 total clinical trials registered on ClinicalTrials.gov.
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