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NCT04436029 · ClinicalTrials.gov registry record · Phase 2
Descartes-11 Consolidation Treatment in Patients With High-Risk Multiple Myeloma Who Have Residual Disease After Induction Therapy
A Phase 2 study, sponsored by Cartesian Therapeutics.
- Completed
- Registry status
- Phase 2
- Development phase
- 5
- Enrollment target
NCT04436029: Completed Phase 2 study, sponsored by Cartesian Therapeutics.
NCT04436029 is a Phase 2 study that has completed, run by Cartesian Therapeutics. The registered enrollment target is 5 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04436029, a Phase 2 study, has completed, sponsored by Cartesian Therapeutics.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 5 participants
- Enrollment target
Study Summary
To assess Minimal Residual Disease (MRD)-negative Complete Response (sCR) rate after consolidation treatment with Descartes-11 in patients with high-risk myeloma who have residual disease following induction therapy.
Primary Outcome
Per IMWG 2016 Response Criteria Summary sCR: Complete response (CR) plus a normal free light chain ratio and no clonal cells in bone marrow (by immunohistochemistry). The FLC ratio must be Kappa/Lambda ≤ 4:1 or ≥ 1:2 after counting at least 100 plasma cells. CR: Negative immunofixation in serum and urine, disappearance of any soft tissue plasmacytomas, and \<5% plasma cells in bone marrow. VGPR: Serum M-protein detectable by immunofixation (not on electrophoresis) or a ≥ 90% reduction in M-prote
Interventions
- BIOLOGICAL Descartes 11
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2021-02-24 |
| Est. Completion | 2022-04-09 |
| Phase | Phase 2 |
What the finished NCT04436029 record still lists
NCT04436029 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 1 intervention - of which Descartes 11 is the first listed.
NCT04436029 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04436029 about?
NCT04436029 is a clinical study titled "Descartes-11 Consolidation Treatment in Patients With High-Risk Multiple Myeloma Who Have Residual Disease After Induction Therapy". To assess Minimal Residual Disease (MRD)-negative Complete Response (sCR) rate after consolidation treatment with Descartes-11 in patients with high-risk myeloma who have residual disease following induction therapy.
What is the current status of trial NCT04436029?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 5 participants. The study started on 2021-02-24. Estimated completion is 2022-04-09.
What interventions are being tested in trial NCT04436029?
The interventions under investigation include: Descartes 11 (BIOLOGICAL).
Who is sponsoring clinical trial NCT04436029?
This trial is sponsored by Cartesian Therapeutics, which has 12 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04436029's enrollment target sits among peer trials
5 2000th of 2000 the lowest of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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