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NCT04422639 · ClinicalTrials.gov registry record · NA
Preoperative SRS/SRT vs Postoperative SRS/SRT for Brain Metastases
A NA study, sponsored by University of Arkansas.
- Terminated
- Registry status
- NA
- Development phase
- 3
- Enrollment target
NCT04422639: Clinical Trial NA study, sponsored by University of Arkansas.
NCT04422639 is a NA study that was terminated before completion, run by University of Arkansas. The registered enrollment target is 3 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04422639, a NA study, was terminated before completion, sponsored by University of Arkansas.
- TERMINATED
- Registry status
- NA
- Development phase
- 3 participants
- Enrollment target
Study Summary
This pilot study is a randomized, open-label, 2-arm active-controlled phase II clinical trial conducted at a single study site (UAMS). Subjects will be randomized to one of the 2 treatment arms and stratified by size of index lesion and number of brain metastases. The investigators will prospectively compare preoperative (neoadjuvant) SRS/SRT to postoperative (adjuvant) SRS/SRT in patients undergoing surgical resection for brain metastases. The investigators hypothesize that neoadjuvant SRS/SRT prior to surgical resection of brain metastases will result in improved freedom from Central Nervous System (CNS) events when compared to adjuvant SRS/SRT after surgical resection.
Primary Outcome
A CNS CE will consist of one of the following three events: Local Recurrence (LR) of the treated lesions, symptomatic radiation necrosis (SRN) to the treated lesions, or development of leptomeningeal disease (LMD).
Interventions
- RADIATION SRS/SRT
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3 participants |
| Start Date | 2020-08-24 |
| Est. Completion | 2023-03-27 |
| Phase | NA |
Why NCT04422639 stopped before completion
NCT04422639 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 3 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 1 intervention - of which SRS/SRT is the first listed.
NCT04422639 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04422639 about?
NCT04422639 is a clinical study titled "Preoperative SRS/SRT vs Postoperative SRS/SRT for Brain Metastases". This pilot study is a randomized, open-label, 2-arm active-controlled phase II clinical trial conducted at a single study site (UAMS). Subjects will be randomized to one of the 2 treatment arms and stratified by size of index lesion and number of brain metastases. The investigators will prospective...
What is the current status of trial NCT04422639?
This trial is currently terminated. It is a NA study. The enrollment target is 3 participants. The study started on 2020-08-24. Estimated completion is 2023-03-27.
What interventions are being tested in trial NCT04422639?
The interventions under investigation include: SRS/SRT (RADIATION).
Who is sponsoring clinical trial NCT04422639?
This trial is sponsored by University of Arkansas, which has 318 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04422639's enrollment target sits among peer trials
3 1996th of 2000 higher than 4 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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