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NCT04421092 · ClinicalTrials.gov registry record · Phase 3
Efficacy of SLN Block for Chronic Cough
A Phase 3 study, sponsored by Medical University of South Carolina.
- Completed
- Registry status
- Phase 3
- Development phase
- 17
- Enrollment target
NCT04421092: Completed Phase 3 study, sponsored by Medical University of South Carolina.
NCT04421092 is a Phase 3 study that has completed, run by Medical University of South Carolina. The registered enrollment target is 17 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04421092, a Phase 3 study, has completed, sponsored by Medical University of South Carolina.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 17 participants
- Enrollment target
Study Summary
This is a research study to find out if superior laryngeal nerve blocks are an effective way to reduce cough when compared to placebo (a substance without any medical value). Eligibility for the study include the following: age \>18, cough history suggestive that the nerve to the voice box is overactive, non-smoker, Patients will be followed over time and assigned to either the treatment or placebo group at random. The treatment would be four superior laryngeal nerve blocks and the placebo would be four saline injections (the inactive substance). Study team will measure if the injection improved cough and ask patients to keep a log of symptoms and fill out questionnaires at each visit. After the four injections, patients will follow up in 3 months to see if cough has returned and if so, how severe the cough is.
Primary Outcome
Patient will complete the Leicester Cough Questionnaire at each visit. This is a validated survey that measures 3 domains (physical, psychological and social). The total score range is 3-21 and domain scores range from 1-7; a higher score indicates a better quality of life.
Interventions
- PROCEDURE Superior laryngeal nerve block
- PROCEDURE Injection of placebo (saline)
- PROCEDURE Injection of steroid-lidocaine mixture
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 17 participants |
| Start Date | 2020-07-22 |
| Est. Completion | 2022-12-30 |
| Phase | Phase 3 |
What the finished NCT04421092 record still lists
NCT04421092 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 17 participants, a relatively small participant target, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 3 interventions - of which Superior laryngeal nerve block is the first listed.
NCT04421092 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04421092 about?
NCT04421092 is a clinical study titled "Efficacy of SLN Block for Chronic Cough". This is a research study to find out if superior laryngeal nerve blocks are an effective way to reduce cough when compared to placebo (a substance without any medical value). Eligibility for the study include the following: age \>18, cough history suggestive that the nerve to the voice box is overac...
What is the current status of trial NCT04421092?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 17 participants. The study started on 2020-07-22. Estimated completion is 2022-12-30.
What interventions are being tested in trial NCT04421092?
The interventions under investigation include: Superior laryngeal nerve block (PROCEDURE), Injection of placebo (saline) (PROCEDURE), Injection of steroid-lidocaine mixture (PROCEDURE).
Who is sponsoring clinical trial NCT04421092?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04421092's enrollment target sits among peer trials
17 1971st of 2000 higher than 27 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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