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NCT04411914 · ClinicalTrials.gov registry record · Phase 1
Pharmaco-Magnetic Resonance Spectroscopy (MRS) Study of Clavulanic Acid
A Phase 1 study, sponsored by Temple University.
- Completed
- Registry status
- Phase 1
- Development phase
- 13
- Enrollment target
NCT04411914: Completed Phase 1 study, sponsored by Temple University.
NCT04411914 is a Phase 1 study that has completed, run by Temple University. The registered enrollment target is 13 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (78% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04411914, a Phase 1 study, has completed, sponsored by Temple University.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 13 participants
- Enrollment target
Study Summary
A dose-escalation study to determine the optimum dose of Clavulanic Acid (CLAV) for effects on craving and efficacy.
Primary Outcome
Brain glutamate concentration in the ACC (based on Magnetic Resonance Spectroscopy (MRS)) will be correlated with cocaine craving (measured by Cocaine Craving Questionnaire (CCQ)) in subjects receiving escalating doses of CLAV for 10 days. Measurement will be made at baseline and Day 10 of CLAV (1000 mg/day) in subjects with cocaine use disorder.
Interventions
- OTHER Placebo
- DRUG Clavulanic Acid
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 13 participants |
| Start Date | 2020-09-01 |
| Est. Completion | 2022-03-31 |
| Phase | Phase 1 |
What the finished NCT04411914 record still lists
NCT04411914 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 13 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (78% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT04411914 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04411914 about?
NCT04411914 is a clinical study titled "Pharmaco-Magnetic Resonance Spectroscopy (MRS) Study of Clavulanic Acid". A dose-escalation study to determine the optimum dose of Clavulanic Acid (CLAV) for effects on craving and efficacy.
What is the current status of trial NCT04411914?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 13 participants. The study started on 2020-09-01. Estimated completion is 2022-03-31.
What interventions are being tested in trial NCT04411914?
The interventions under investigation include: Placebo (OTHER), Clavulanic Acid (DRUG).
Who is sponsoring clinical trial NCT04411914?
This trial is sponsored by Temple University, which has 163 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04411914's enrollment target sits among peer trials
13 1847th of 2000 higher than 149 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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