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NCT04384484 · ClinicalTrials.gov registry record · Phase 3
Study to Evaluate Loncastuximab Tesirine With Rituximab Versus Immunochemotherapy in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
A Phase 3 study of Refractory Diffuse Large B-Cell Lymphoma and Relapsed Diffuse Large B-cell Lymphoma, sponsored by ADC Therapeutics S.A..
- Active
- Registry status
- Phase 3
- Development phase
- 440
- Enrollment target
- 20
- Study locations
NCT04384484 is a Phase 3 study of Refractory Diffuse Large B-Cell Lymphoma and Relapsed Diffuse Large B-cell Lymphoma that is active but no longer recruiting, run by ADC Therapeutics S.A.. The registered enrollment target is 440 participants, above the 52-participant average among 37 other Refractory Diffuse Large B-Cell Lymphoma trials with a reported enrollment target (746% higher). The trial reports 20 study locations across 14 states.
The verdict
NCT04384484, a Phase 3 study of Refractory Diffuse Large B-Cell Lymphoma and Relapsed Diffuse Large B-cell Lymphoma, is active but no longer recruiting, sponsored by ADC Therapeutics S.A..
- ACTIVE NOT RECRUITING
- Registry status
- Phase 3
- Development phase
- 440 participants
- Enrollment target
- 20
- Study locations
Study Summary
The purpose of this study is to evaluate the efficacy of loncastuximab tesirine (ADCT-402) combined with rituximab compared to standard immunochemotherapy.
Conditions Studied
Interventions
- DRUG Oxaliplatin
- DRUG Rituximab
- DRUG Gemcitabine
- DRUG Loncastuximab Tesirine
Study Locations (20)
Other
- Algemeen Ziekenhuis Sint-Jan Brugge-Oostende - Campus Sint-Jan - Bruges
- Cliniques Universitaires Saint-Luc - Brussels
- Centre Hospitalier Universitaire Universite Catholique de Louvain - Namur
- Algemeen Ziekenhuis Delta - Campus Rumbeke - Roeselare
California
- University of California San Diego Moores Cancer Center - La Jolla
- Redlands Community Hospital - Redlands
- The Oncology Institute of Hope and Innovation - Whittier
Buenos Aires
- Clinica Adventista Belgrano - Belgrano
- Clínica de Nefrología, Urología y Enfermedades Cardiovasculares S.A. - Santa Fe
Florida
- Baptist MD Anderson Cancer Center - Jacksonville
Iowa
- UnityPoint Health - Iowa Oncology Research Association (IORA) - Des Moines
Kentucky
- Norton Cancer Institute - Louisville
Nevada
- Comprehensive Cancer Centers of Nevada - Henderson - Las Vegas
Oregon
- Kaiser Permanente Interstate Medical Office Central - Portland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 440 participants |
| Start Date | 2020-09-16 |
| Est. Completion | 2028-06-30 |
| Phase | Phase 3 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04384484
The ClinicalTrials.gov registry entry for NCT04384484 describes a study currently listed as active not recruiting, categorized as Phase 3. The registered enrollment target is 440 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 52-participant average among 37 other Refractory Diffuse Large B-Cell Lymphoma trials with a reported enrollment target (746% higher). The listed sponsor is ADC Therapeutics S.A., which has 18 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Refractory Diffuse Large B-Cell Lymphoma appearing as the primary indexed condition, and to 4 interventions - of which Oxaliplatin is the first listed.
NCT04384484 reports 20 study locations spanning 14 distinct geographic areas - top geographies include Other, California, Buenos Aires.
Frequently Asked Questions
What is clinical trial NCT04384484 about?
NCT04384484 is a clinical study titled "Study to Evaluate Loncastuximab Tesirine With Rituximab Versus Immunochemotherapy in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma". The purpose of this study is to evaluate the efficacy of loncastuximab tesirine (ADCT-402) combined with rituximab compared to standard immunochemotherapy.
What is the current status of trial NCT04384484?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 440 participants. The study started on 2020-09-16. Estimated completion is 2028-06-30.
What conditions does trial NCT04384484 study?
This clinical trial studies the following conditions: Refractory Diffuse Large B-Cell Lymphoma, Relapsed Diffuse Large B-cell Lymphoma.
What interventions are being tested in trial NCT04384484?
The interventions under investigation include: Oxaliplatin (DRUG), Rituximab (DRUG), Gemcitabine (DRUG), Loncastuximab Tesirine (DRUG).
Who is sponsoring clinical trial NCT04384484?
This trial is sponsored by ADC Therapeutics S.A., which has 18 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04384484 being conducted?
This trial has 20 study locations across California, Florida, Iowa, Kentucky, Nevada. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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